Ascertaining the neural basis of attachment disorder and oxytocin effect using fMRI
| Project/Area Number |
25560386
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Childhood science (childhood environment science)
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| Research Institution | University of Fukui |
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Principal Investigator |
TOMODA AKEMI 福井大学, 子どものこころの発達研究センター, 教授 (80244135)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJISAWA TAKASHI 福井大学, 子どものこころの発達研究センター, 特命助教 (90434894)
KUMAZAKI HIROKAZU 福井大学, 子どものこころの発達研究センター, 特命助教 (70445336)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 発達・環境 / 反応性愛着障害 / オキシトシン / 脳画像解析 / ｆMRI / 金銭報酬課題 / 線条体 / アタッチメント / ｆＭＲＩ / 発達・教育 / オキシトシン治療 / 反応性愛着 / 顔表情認知課題 / アタッチメント障害 |
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| Outline of Final Research Achievements |
Childhood maltreatment, which markedly increases risk for psychopathology, is associated with structural and functional brain differences. Our earlier studies elucidated potential discernible effects on brain morphology of child abuse such as parental verbal abuse on gray matter volume or cortical thickness. Brain regions that process and convey the adverse sensory input of the abuse might be modified specifically by such experiences.
Using tasks with reading the mind in the eyes test while undergoing fMRI, we also examined whether neural activity during reward processing was altered, or not, in children and adolescents with reactive attachment disorder（RAD）. Significantly reduced activity in the putamen was observed in the RAD group compared to the typically developed group. The present results suggest that dopaminergic dysfunction occurred in the putamen in children and adolescents with RAD, potentially leading to a future risk of psychiatric disorders such as dependence.
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Report
(4 results)
Research Products
(71 results)
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[Journal Article] Family based association study of ZNF533, DOCK4 and IMMP2L gene polymorphisms linked to Autism in a Han population in northeastern China.2014
Author(s)
Liang S, Wang X, Zoua M, Wanga H, Zhoua X, Suna C, Xia W, Wu L*, Fujisawa TX, Tomoda A.
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Journal Title
J Zhejiang Univ Sci B
Volume: 15(3)
Issue: 3
Pages: 264-71
DOI
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Peer Reviewed / Open Access
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[Journal Article] Effectiveness and tolerability of switching to aripiprazole from risperidone in subjects with Pervasive Developmental Disorders: A prospective open-label study.2013
Author(s)
Ishitobi M, Kosaka H, Takahashi T, Yatsuga C, Asano M, Tanaka Y, Ueno K, Okazaki R, Omori M, Hiratani M, Tomoda A, Wada Y.
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Journal Title
Clinical Neuropharmacology
Volume: 36
Issue: 5
Pages: 151-156
DOI
Related Report
Peer Reviewed
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[Presentation] 被虐待者の脳科学研究2015
Author(s)
友田明美.
Organizer
第111回日本精神神経学会学術総会 教育講演
Place of Presentation
大阪市、大阪国際会議場
Year and Date
2015-06-05
Related Report
Invited
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[Presentation] Low striatal activity during reward perception caused by childhood adversity.2015
Author(s)
Takiguchi S, Fujisawa TX, Mizushima S, Saito DN, Kumazaki H, Koizumi M, Shimada K, Okamoto Y, Jung M, Kosaka H, Tomoda A.
Organizer
第57回日本小児神経学会 English Session 4（口頭発表）
Place of Presentation
大阪市、帝国ホテル
Year and Date
2015-05-29
Related Report
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[Presentation] Reward sensitivity dysfunction in children and adolescents with reactive attachment disorder.2015
Author(s)
Takiguchi S, Fujisawa TX, Mizushima S, Saito DN, Okamoto Y, Shimada K, Kumazaki H, Koizumi M, Jung M, Kosaka H, Tomoda A.
Organizer
The 13th Asian and Oceania Congress of Child Neurology (2015 AOCCN) （口頭発表）
Place of Presentation
Taipei City, Taiwan
Year and Date
2015-05-15
Related Report
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[Presentation] 小児期逆境体験による線条体への影響：報酬系課題を用いたfMRI研究.2014
Author(s)
滝口慎一郎, 藤澤隆史, 水島栄, 齋藤大輔, 熊崎博一, 小泉径子, 島田浩二, 岡本悠子, 丁ミンヨン, 小坂浩隆, 友田明美
Organizer
2014年度 包括脳ネットワーク 冬のシンポジウム
Place of Presentation
東京、東京医科歯科大学湯島キャンパス
Year and Date
2014-12-12
Related Report
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[Presentation] Preliminary fMRI study during the reward task in children and adolescents with Reactive Attachment Disorder.2014
Author(s)
Takiguchi S, Kumazaki H, Mizushima S, Saito DN, Kumazaki H, Koizumi M, Shimada K, Okamoto Y, Jung M, Kosaka H, Tomoda A.
Organizer
XXth ISPCAN International Congress on Child Abuse and Neglect
Place of Presentation
Nagoya、名古屋国際会議場
Year and Date
2014-09-14
Related Report
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[Presentation] FMRI study of the reward system of pediatric patients with Reactive Attachment Disorder.
Author(s)
Takiguchi S, Fujisawa TX, Saito DN, Yatsuga C, Kumazaki H, Mizushima S, Aoi T, Kojima M, Naruse H, Koizumi M, Jung M, Kosaka H, Tomoda A
Organizer
International Workshop on Molecular Functional Imaging for Brain and Gynecologic Oncology (Fukui2014: The Fifth International Workshop on Biomedical Imaging)（ポスター発表）
Place of Presentation
Fukui、Yours Hotel Fukui
Related Report
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