Alternation of organ function in mice of jet-lag model

• Project/Area Number: 25560426
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Basic / Social brain science
• Research Institution: Kyoto University
• Principal Investigator: OKAMURA Hitoshi 京都大学, 薬学研究科(研究院), 教授 (60158813)
• Project Period (FY): 2013-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: 脳とリズム / 時差 / 生活習慣病 / シフトワーク / 視交叉上核 / 体重増加

Research Abstract

Timed activities such as eating and sleeping are crucial for a comfortable social life and healthy living. As the living environment changes rapidly, and the numbers of around-the-clock facilities and people staying awake all night increase the convenience of consumers and the productivity of industries, the biological system to regulate our internal rhythms is being compromised. From screening the knockout of a variety of genes expressed in the SCN, here we identified the mice which do not show jet-lag even when they exposed suddenly to the 8-hour phase advance. We identified that the local circuits of vasopressin/V1aV1b-receptors in the SCN are crucial for jet-lag formation. From the analysis of chronic jet lag conditions, we want to clarify the mechanism of a life-style related disease evoked by chronic jet-lag.

Research Products

• [Journal Article] Mice genetically deficient in vasopressin V1a and V1b receptors are resistant to jet lag (2013)
  • Author(s): Yamaguchi Y, Suzuki T, Mizoro Y, Kori H, Okada K, Chen Y, Fustin JM, Yamazaki F, Mizuguchi N, Zhang J, Dong X, Tsujimoto G, Okuno Y, Doi M, Okamura H
  • Journal Title: Science Volume: 342 Pages: 85-90
  • Peer Reviewed
• [Journal Article] RNA-methylation- dependent RNA processing controls the speed of the circadian clock (2013)
  • Author(s): Fustin JM, Doi M, Yamaguchi Y, Hayashi H, Nishimura S, Yoshida M, Isagawa T, Suimye-Morioka M, Kakeya H, Manabe I, Okamura H
  • Journal Title: Cell Volume: 155 Pages: 793-806
  • Peer Reviewed
• [Journal Article] Mice Genetically Deficient in Vasopressin V1a and V1b Receptors Are Resistant to Jet Lag (2013)
  • Author(s): Yamaguchi Y, Suzuki T, Mizoro Y, Kori H, Okada K, Chen Y, Fustin JM, Yamazaki F, Mizuguchi N, Zhang J, Dong X, Tsujimoto G, Okuno Y, Doi M, Okamura H
  • Journal Title: Science Volume: 342 Issue: 6154 Pages: 85-90
  • DOI: 10.1126/science.1238599
  • Peer Reviewed
• [Journal Article] RNA-methylation-dependent RNA processing controls the speed of the circadian clock (2013)
  • Author(s): Fustin JM, Doi M, Yamaguchi Y, Hayashi H, Nishimura S, Yoshida M, Isagawa T, Suimye-Morioka M, Kakeya H, Manabe I, Okamura H
  • Journal Title: Cell Volume: 155 Issue: 4 Pages: 793-806
  • DOI: 10.1016/j.cell.2013.10.026
  • Peer Reviewed
• [Presentation] New inter- and intracellular regulation of the circadian pacemaker (2014)
  • Author(s): Okamura H
  • Organizer: SRBR 2014
  • Place of Presentation: Big Sky (Montana USA)
  • Invited
• [Presentation] (2014)
  • Author(s): 岡村均
  • Organizer: 第51回日本臨床分子医学会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
• [Presentation] クロノメタボリズム：時間相の医学生物学 (2014)
  • Author(s): 岡村均
  • Organizer: 第51回日本臨床分子医学会学術集会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Invited
• [Presentation] New inter- and intracellular regulations of the circadian pacemaker (2014)
  • Author(s): Hitoshi Okamura
  • Organizer: The 2014 Meeting of the Society for Research on Biological Rhythms
  • Place of Presentation: Big Sky （Montana 米国）
  • Invited