| Project/Area Number |
25560432
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Brain biometrics
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| Research Institution | University of Yamanashi (2014)
The University of Tokyo (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 神経科学 / 生理学 / 光遺伝学 / 運動 / オプトジェネティクス / 大脳 / 小脳 |
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| Outline of Final Research Achievements |
Interplay between the cerebellum and the neocortex is crucial for the execution of skilled movement and motor learning. To elucidate comprehensive functional connections between the neocortex and the cerebellar cortex, here we perform cell-attached recordings from the cerebellar Purkinje cell while layer 5 pyramidal neurons located at various area of the cerebral cortex are optogenetically stimulated in Thy1-ChR2-EYFP mice. Photostimulation reliably evokes simple and complex spikes, which are respectively induced by parallel and climbing fiber inputs, in the Purkinje cell with distinct spike probabilities and different latencies. Accordingly, we identify spatial and temporal spike maps on the cerebral cortex including sensory and motor area. The results indicate that specific areas of cerebellum are closely associated with motor and sensory area, thus implying these information are integrated in the specific cerebellar regions so as to control accurate coordination of movement.
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