| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
To decipher the relationship between plasticity and dendritic backpropagations of hippocampal place cells, we developed a novel technique that selectively stimulates specific types of neurons and records both neuronal and EEG activities simultaneously. The core of the technique, called microdrive, is capable of independently moving recording electrodes and optic fibers for optical stimulation. Using the microdrive, we activated the activity of parvalbumin (PV) positive neurons at some frequencies. The results suggested that the firing rates of pyramidal neurons and coherence between stimulation pattern and pyramidal cells’ firings increased within specific frequency ranges. Using the present method to manipulate dendritic backpropagations, we will elucidate the relationship between plasticity and dendritic backpropagations.
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