| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Outline of Final Research Achievements |
Brain functions are controlled by the complicated neural circuit. In order to understand brain functions, we need to analyze each specific neural pathway, a component of the neural circuit. Rho GTPase signaling pathway via Rho-kinase, one of the major effector molecules of Rho, is becoming increasingly clear to regulate various neuronal functions. In the present study, by using a dual viral vector approach combining a neuron-specific retrograde gene transfer lentiviral vector and an adeno-associated virus vector, we demonstrated that the Rho/Rho-kinase signaling pathway was essential for the survival of cortical neurons forming the corticostriatal pathway.
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