The creation of molecular quasi-crystals by DNA self-assembly

• Project/Area Number: 25600003
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Nanostructural chemistry
• Research Institution: Nagoya University
• Principal Investigator: Tagawa Miho 名古屋大学, 未来材料・システム研究所, 准教授 (40512330)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: ナノ粒子 / DNA / 準結晶 / self-assembly / nanoparticle / Nanoparticle / DNA self-assembly / 分子準結晶 / 階層構造 / 超構造 / 5回対称

Outline of Final Research Achievements

(1) The creation of quasicrystals by double-encoded DNA functionalized nanoparticles (DNA-NPs) on supported lipid bilayer (SLB). DNA-NPs, which were encoded by two types of DNA single-strands, were diffused, assembled and crystallized on SLB. Two-lengthscale particle formations were realized by using the double-encoded DNA-NPs.
(2) Nanoparticle quasicrystal assembly mediated by designed DNA nanostructures. DNA-NPs were assembled by using DNA tetrahedral constructs. We studied optimum conditions of the lengths of DNA linkers and base sequences of recognition sites for assembling nanoparticle quasicrystals.

Research Products

• [Int'l Joint Research] Brookhaven National Laboratory/Wasleyan University/Stony Brook University(米国)
• [Journal Article] Diamond Family of Nanoparticle Superlattices (2016)
  • Author(s): Wenyan Liu, Miho Tagawa, Huolin Xin, Tong Wang, Hamed Emamy, Huilin Li, Kevin G. Yager, Francis W. Starr, Alexei V. Tkachenko, Oleg Gang
  • Journal Title: Science Volume: 351 Issue: 6273 Pages: 582-586
  • DOI: 10.1126/science.aad2080
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effect of magnesium ion concentration on two-dimensional structure of DNA-functionalized nanoparticles on supported lipid bilayer (2016)
  • Author(s): Takumi Isogai, Eri Akada, Sakiko Nakada, Naoya Yoshida, Ryugo Tero, Shunta Harada, Toru Ujihara, Miho Tagawa
  • Journal Title: Japanese Journal of Applied Physics Volume: 55 Issue: 3S2 Pages: 03DF11-03DF11
  • DOI: 10.7567/jjap.55.03df11
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Forming two-dimensional structure of DNA-functionalized Au nanoparticles via lipid diffusion in supported lipid bilayers (2014)
  • Author(s): T. Isogai, A. Piednoir, E. Akada, Y. Akahoshi, R. Tero, S. Harada, T. Ujihara and M. Tagawa
  • Journal Title: J. Cryst .Growth Volume: 未定 Pages: 494-498
  • DOI: 10.1016/j.jcrysgro.2014.01.032
  • Peer Reviewed
• [Presentation] DDAB平面脂質二重膜の相転移過程の直接観察 (2016)
  • Author(s): 磯貝卓巳，中田咲子，赤田英里，吉田直矢，鷲見隼人，手老龍吾，原田俊太，宇治原徹，田川美穂
  • Organizer: 第63回応用物理学会春季学術講演会
  • Place of Presentation: 東工大大岡山キャンパス
  • Year and Date: 2016-03-19
• [Presentation] Effect of Magnesium Ion Concentration on the Two-Dimensional Structure of DNA-Functionalized Nanoparticles on Supported Lipid Bilayer (2015)
  • Author(s): Takumi Isogai, Eri Akada, Sakiko Nakada, Naoya Yoshida, Ryugo Tero, Shunta Harada, Toru Ujihara, Miho Tagawa
  • Organizer: 8th International Conference on Molecular Electronics and Bioelectronics
  • Place of Presentation: Tower Hall Funabori, Tokyo, Japan
  • Year and Date: 2015-06-22 – 2015-06-24
• [Presentation] Lipid diffusion and phase transition: Influence on DNA-functionalised nanoparticle adsorbates (2015)
  • Author(s): Sakiko Nakada, Eri Akada, Takumi Isogai, Ryugo Tero, Shunta Harada, Toru Ujihara, Miho Tagawa
  • Organizer: 5th International Colloids Conference
  • Place of Presentation: Amsterdam, The Netherlands
  • Year and Date: 2015-06-21 – 2015-06-24
• [Presentation] 脂質二重膜上におけるDNA被覆金ナノ粒子のセルフアセンブリに対するイオンの効果 (2015)
  • Author(s): 磯貝 卓巳，赤田 英里，中田 咲子，吉田 直矢，手老 龍吾，原田 俊太，宇治原 徹，田川 美穂
  • Organizer: 第６２回応用物理学会春季学術講演会
  • Place of Presentation: 東海大学，湘南キャンパス，神奈川県
  • Year and Date: 2015-03-11 – 2015-03-14
• [Presentation] Two-dimensional assembly of Au nanoparticles through DNA hybridization on supported lipid bilayer (2014)
  • Author(s): T. Isogai, E. Akada, S. Nakada, R. Tero, S. Harada, T. Ujihara and M. Tagawa
  • Organizer: 20th International Conference on DNA Computing and Molecular Programming (DNA20)
  • Place of Presentation: Kyoto University, Kyoto, Japan
  • Year and Date: 2014-09-22 – 2014-09-26
• [Presentation] 脂質二重膜上におけるDNA被覆金ナノ粒子の拡散現象 (2014)
  • Author(s): 中田咲子，赤田英里， 磯貝卓巳，手老龍吾，原田俊太，宇治原徹，田川美穂
  • Organizer: 第75回応用物理学会秋季学術講演会
  • Place of Presentation: 北海道大学札幌キャンパス, 北海道
  • Year and Date: 2014-09-17 – 2014-09-20
• [Presentation] DNA-mediated Nanoparticle Crystallization (2014)
  • Author(s): Miho Tagawa, Oleg Gang, Takumi Isogai, Sakiko Nakada, Eri Akada, Shunta Harada, Toru Ujihara
  • Organizer: The International Symposium on Material Architectonics for Sustainable Action (MASA)
  • Place of Presentation: NIMS, Tsukuba, Japan
  • Year and Date: 2014-07-18
  • Invited
• [Presentation] ＤＮＡと基板担持脂質二重膜とを用いたナノ粒子の結晶化 (2014)
  • Author(s): 田川美穂
  • Organizer: 応用物理学会 有機分子・バイオエレクトロニクス分科会 研究会
  • Place of Presentation: キャンパスプラザ京都, 京都府
  • Year and Date: 2014-06-21
  • Invited
• [Presentation] 基板担持脂質二重膜を用いたDNA被覆金ナノ粒子の2次元結晶化 (2014)
  • Author(s): 磯貝卓巳，赤田英里，Piednoir Agnes，赤星祐樹，手老龍吾，原田俊太，宇治原徹，田川美穂
  • Organizer: 日本化学会第94春季年回
  • Place of Presentation: 名古屋大学
• [Presentation] Two-dimensional crystallization of DNA-functionalized Au nanoparticles using lipid diffusion (2013)
  • Author(s): Takumi Isogai, Eri Akada, Agnes Piednoir, Yuki Akahoshi, Ryugo Tero, Shunta Harada, Toru Ujihara, Miho Tagawa
  • Organizer: ISETS '13
  • Place of Presentation: Nagoya University
• [Presentation] DNAと脂質二重膜を用いたナノ粒子の2次元結晶化 (2013)
  • Author(s): 磯貝卓巳，赤田英里，Agnes Piednoir，赤星祐樹，手老龍吾，原田俊太，宇治原徹，田川美穂
  • Organizer: 日本結晶成長学会第43回結晶成長国内会議（NCCG-43）
  • Place of Presentation: 長野市生涯学習センター （TOiGO内）, 長野県
• [Presentation] ブラウニアン動力学法を用いた2次元2成分結晶の構造形成シミュレーション (2013)
  • Author(s): 勝野弘康，田川美穂，宇治原徹
  • Organizer: 日本結晶成長学会第43回結晶成長国内会議（NCCG-43）
  • Place of Presentation: 長野市生涯学習センター （TOiGO内）, 長野県
• [Presentation] DNAセルフアセンブリによるナノ粒子超構造制御 (2013)
  • Author(s): 田川 美穂, ガング オレグ, 磯貝 卓巳, 赤田 英里, 宇治原 徹
  • Organizer: 第 51 回日本生物物理学会年会 シンポジウム 反応場デザインによる生命現象の再構成 -創って知る生物物理-
  • Place of Presentation: 国立京都国際会館, 京都府
  • Invited
• [Presentation] DNA-mediated Nanoparticle Assembly (2013)
  • Author(s): Miho Tagawa, Takumi Isogai, Eri Akada, Shunta Harada, Toru Ujihara
  • Organizer: The 2nd International Workshop on Convergence in Condensed Matter and Nano Physics
  • Place of Presentation: Sungkyunkwan University, Korea
  • Invited
• [Presentation] 脂質分子をキャリアとしたDNA被覆金ナノ粒子の2次元結晶化 (2013)
  • Author(s): 磯貝卓巳，Agnes Piednoir，赤田英里，赤星祐樹，手老龍吾，原田俊太，宇治原徹，田川美穂
  • Organizer: 脂質分子をキャリアとしたDNA被覆金ナノ粒子の2次元結晶化
  • Place of Presentation: 同志社大学京田辺キャンパス, 京都府
• [Presentation] Forming two-dimensional structure of DNA-functionalized Au nanoparticles via lipid diffusion in supported lipid bilayers (2013)
  • Author(s): Takumi Isogai, Agnes Piednoir, Eri Akada, Yuki Akahoshi, Ryugo Tero, Shunta Harada, Toru Ujihara, Miho Tagawa
  • Organizer: 17th International Conference on Crystal Growth and Epitaxy (ICCGE-17)
  • Place of Presentation: University of Warsaw, Warsaw, Poland
• [Presentation] Two-dimensional crystallization of DNA-functionalized nanoparticles via lipid diffusion in supported lipid bilayers (2013)
  • Author(s): Takumi Isogai, Agnes Piednoir, Eri Akada, Yuki Akahoshi, Ryugo Tero, Shunta Harada, Toru Ujihara, Miho Tagawa
  • Organizer: 15th International Summer School on Crystal Growth(ISSCG-15)
  • Place of Presentation: Gdansk University of Technology Gdansk, Poland
• [Presentation] Miho Tagawa, Oleg Gang, Kevin Yanger, Takumi Isogai, Eri Akada, Shunta Harada, Toru Ujihara (2013)
  • Author(s): Nanoparticle Assembly mediated by Designed DNA Nanostructures
  • Organizer: Programmable Self-Assembly of Matter Conference 2013
  • Place of Presentation: Courant Institute of NYU, New York City, USA
• [Remarks] 名古屋大学教員詳細
  • URL: http://profs.provost.nagoya-u.ac.jp/view/html/100006436_ja.html
• [Remarks] 名古屋大学大学院工学研究科マテリアル理工学専攻材料工学分野
  • URL: http://www.numse.nagoya-u.ac.jp/ujihara/
• [Patent(Industrial Property Rights)] ２次元ナノ粒子構造体及びその製造方法 (2013)
  • Inventor(s): 田川美穂、宇治原徹、磯貝卓巳、赤田英里
  • Industrial Property Rights Holder: 田川美穂、宇治原徹、磯貝卓巳、赤田英里
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-126144
  • Filing Date: 2013-06-14