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Development of a nanopore trapping method for identification of single-viruses

Research Project

Project/Area Number 25600061
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Nano/Microsystems
Research InstitutionOsaka University

Principal Investigator

TSUTSUI Makusu  大阪大学, 産業科学研究所, 准教授 (50546596)

Project Period (FY) 2013-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywordsナノポア / センサー / 電気泳動 / ナノ粒子
Research Abstract

This research aims to develop a nanopore trapping method for identification of analytes via transverse current measurements. It is demonstrated that single-particles can be trapped/detrapped repeatedly at a nanopore by electrophoretic voltage control. Upon trapping, ion current through a pore drops due to partial blockade of ion transport through the pore by the trapped particles, the electrical signals of which are found useful in discriminating the surface charge status. Transverse current measurements are also performed by using two electrodes embedded in a nanopore. Measuring the current through these electrodes, the current shows pulse-like changes synchronously to the particle trap at a pore. This is attributable to a change in the properties of electric double layers on electrodes' suface. Overall, it is shown that the transverse current approach can be a new method capable of identifying analytes not by their volume but other properties such as surface charge densities.

Report

(2 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (5 results)

All 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Trapping and Identifying Single-Nanoparticles Using a Low-Aspect-Ratio Nanopore2013

    • Author(s)
      Makusu TSUTSUI, Yoichi MAEDA, Yuhui HE, Sadato HONGO, Sou RYUZAKI, Satoyuki KAWANO, Tomoji KAWAI, and Masateru TANIGUCHI
    • Journal Title

      Applied Physics Letters

      Volume: 103 Issue: 1 Pages: 23112-23112

    • DOI

      10.1063/1.4813084

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Controlling particle position using a nanopore trapping method2013

    • Author(s)
      Y. Maeda, M. Tsutsui, K. Doi, S. Kawano, T. Kawai, M. Taniguchi
    • Organizer
      MicroTAS 2013
    • Place of Presentation
      Freiberg, Germany
    • Year and Date
      2013-10-30
    • Related Report
      2013 Final Research Report
  • [Presentation] ナノポアトラップ法による単一粒子の識別2013

    • Author(s)
      前田陽一, 筒井真楠, 土井謙太郎, 川野聡恭, 川合知二, 谷口正輝
    • Organizer
      第74回応用物理学会秋季学術講演会
    • Place of Presentation
      同志社大学
    • Year and Date
      2013-09-16
    • Related Report
      2013 Final Research Report
  • [Presentation] ナノポアトラップ法による単一粒子の識別2013

    • Author(s)
      前田陽一、筒井真楠、土井謙太郎、川野聡恭、川合知二、谷口正輝
    • Organizer
      第74回応用物理学会秋季学術講演会
    • Place of Presentation
      同志社大学、京田辺市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Controlling particle position using a nanopore trapping method2013

    • Author(s)
      Yoichi Maeda, Makusu Tsutsui, Kentaro Doi, Satoyuki Kawano, Tomoji Kawai, Masateru Taniguchi
    • Organizer
      MicroTAS 2013
    • Place of Presentation
      Freiburg, Germany
    • Related Report
      2013 Annual Research Report

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Published: 2014-07-25   Modified: 2016-11-25  

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