Development of surface modification processes of a dialysis membrane for long-term use of micro hemodialysis devices
| Project/Area Number |
25600064
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nano/Microsystems
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| Research Institution | Keio University |
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Principal Investigator |
MIKI Norihisa 慶應義塾大学, 理工学部, 准教授 (70383982)
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| Co-Investigator(Renkei-kenkyūsha) |
KANNO Yoshihiko 東京医科大学, 医学部, 主任教授 (30276232)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | マイクロ･ナノデバイス / 医療･福祉 / 人工臓器 / 微細加工 / 表面処理 / 成膜技術 / マイクロ・ナノデバイス / 医療・福祉 / MEMS / 医療応用 / 成膜 / 表面改質 / ナノポーラス膜 / 透析 |
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| Outline of Final Research Achievements |
Patients suffering from kidney diseases need to visit hospitals for hemodialysis treatment 3 times a week, which deteriorates their quality of life. Wearable or implantable micro hemodialysis systems would not only improve the QoL but also alleviate the damage onto the patients health due to its rather slow dialysis treatment (24 hours x 7 days). Such hemodialysis devices, however, need to overcome the biofouling originating from the blood.
In this work, we attempted to modify the surface property of the dialysis membrane while maintaining the diffusion capacity by depositing nano-porous thin films. Parylene and fluorinated diamond like carbon were tested. First we developed the deposition processes of the nanoporous films and then, experimentally verified the effectiveness of the surface modification using whole cow blood. 28-days-long experiments showed successful reduction of adhesion of biomaterials by the surface modification.
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Report
(3 results)
Research Products
(21 results)
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[Presentation] 埋め込み型マイクロ透析装置の開発2014
Author(s)
藤 直也, 真田一平, 伊藤 昂, 森田伸也,菅野義彦, 三木則尚
Organizer
ロボティクス・メカトロニクス講演会2014
Place of Presentation
富山国際会議場（富山県・富山市）
Year and Date
2014-05-26 – 2014-05-28
Related Report
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[Presentation] 長期にわたるマイクロ透析装置の使用評価2014
Author(s)
真田一平, 伊藤 昂, G. S. Prihandana, G. Ye, 登坂万結, 鈴木哲也, 菅野義彦, 三木則尚
Organizer
ロボティクス・メカトロニクス講演会2014
Place of Presentation
富山国際会議場（富山県・富山市）
Year and Date
2014-05-26 – 2014-05-28
Related Report
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[Presentation] No-dialysate micro hemodialysis system2013
Author(s)
H. Ito， I.Sanada， Gunawan Setia Prihandana， M. Hayashi， Y.Kanno， N.Miki
Organizer
The 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Place of Presentation
Freiburg, Germany
Related Report
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