| Project/Area Number |
25600071
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied materials
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| Research Institution | Tohoku University |
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Principal Investigator |
NIWANO Michio 東北大学, 電気通信研究所, 教授 (20134075)
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| Co-Investigator(Kenkyū-buntansha) |
HIRANO Ayumi (IWATA Ayumi) 東北大学, 医工学研究科, 准教授 (80339241)
KIMURA Yasuo 東京工科大学, コンピュータサイエンス学部, 教授 (40312673)
YAMAMOTO Hideaki 東北大学, 学際科学フロンティア研究所, 助教 (10552036)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ニューロエレクトロニクス / 信号伝達 / 培養神経細胞 / 神経回路 / シナプス / タンパク質 / マイクロパターニング / 表面改質 / バイオエレクトロニクス / 培養細胞 / 人工神経回路網 / 基板表面 / パターニング |
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| Outline of Final Research Achievements |
Human brain is a complex, hierarchical system comprised of 10 billion neurons. By engineering a simple neuronal network in vitro that mimics the in vivo architecture and functions, a novel system for studying of the dynamical properties of the neuronal networks in the brain will become available.
In the current project, we developed a series of surface micromodification techniques for fabricating "template" surfaces for neuronal cell patterning. We then evaluated the spontaneous activity of the micropatterned neuronal networks via fluorescent calcium imaging. A simulation model of neuronal networks based on a biophysical model was also developed to theoretically investigate activity modulation in micropatterned networks.
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