| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Nanodisc is a discoidal lipid-polypeptide complex, which possesses a minimum unit of lipid bilayer. In this study, we clarified influence of the composition of lipids and the structural characteristics of polypeptides on the formation and stability of nanodiscs by physicochemical approaches. In addition, we succeeded in newly constructing systems of self-replication and rouleaux-formation of nanodiscs. These findings will contribute to construction of a molecular basis of these nanoparticles and to their development and application.
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