Homociral world in the prebiotic world

• Project/Area Number: 25610165
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Geochemistry/Cosmochemistry
• Research Institution: Fukuoka Institute of Technology
• Principal Investigator: MITA Hajime 福岡工業大学, 工学部, 教授 (00282301)
• Co-Investigator(Renkei-kenkyūsha): NAGASAWA Eriko 福岡工業大学大学院, 工学研究科
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: アミノ酸 / ポリアミノ酸 / 化学進化 / ホモキラル / ミクロスフェア / プロテノイド / ジアステレオマー / プロテノイドミクロスフェア / マイクロマニュピレーション / ペプチド

Outline of Final Research Achievements

Purpose of this study is to clarify the process of homochiral worlds expressed in our biosphere from a slight asymmetrical compounds that are believed to have expressed in a space environment. We added a chiral amino acid without racemization during the experiment is added into the prebiotic polyamino acids (proteinoids) producing systems. Then, the chirality of the products would be analyzed.
Molten state experiment of monoammonium malate was used the proteinoid formation. Racemic alanine and chiral isovaline were added into the reaction. LC-MS analysis of the products indicated the possibility that optically active proteinoids were produced.

Research Products

• [Journal Article] Design of a silica-aerogel-based cosmic dust collector for the Tanpopo mission aboard the International Space Station (2014)
  • Author(s): Tabata, M., Imai, I., Yano, H., Hashimoto, H., Kawai, I., Kawaguchi, Y., Kobayashi, K., Mita, H., Okudaira, K., Sasaki, S., Yabuta, Y., Yokobori, Y., and Yamagishi, A.
  • Journal Title: Trans. Jn Soc. Aeronaut. Space Sci.
  • NAID: 130004679634
  • Peer Reviewed
• [Journal Article] The Effect of Metylene Chain Length in Head Group of Amin Acid-Based Surfactants (2014)
  • Author(s): Higashi, S., Sueyoshi, M., Kuwahara, J., Mita, H., Watanabe, W., Kato, T.
  • Journal Title: Peptide Sci. Volume: 2014
  • Peer Reviewed
• [Presentation] Prebiotic polyamino acid formation under molten states (2015)
  • Author(s): Mita Hajime, Nagasawa riko, Nomoto Shinya
  • Organizer: Pacifichem 2015
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2015-12-15 – 2015-12-20
• [Presentation] Structure analysis of cooligomers in thermal proteinoids (2015)
  • Author(s): Nagasawa Eriko, Mita Hajime
  • Organizer: Pacifichem 2015
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2015-12-15 – 2015-12-20
• [Presentation] 前生物的に合成したポリアミノ酸のLC-MS解析 (2015)
  • Author(s): 三田肇、永沢恵理子
  • Organizer: 日本化学会第95回春季年会
  • Place of Presentation: 日本大学、船橋市
  • Year and Date: 2015-03-26 – 2015-03-29
• [Presentation] プロテノイド共重合体の構造解析 (2015)
  • Author(s): 永沢恵理子、三田肇
  • Organizer: 生命の起原および進化学会第40回学術講演会
  • Place of Presentation: 東京理科大学、葛飾区
  • Year and Date: 2015-03-15 – 2015-03-17
• [Presentation] Protenoid microsphere foremation in the thermal polycondensation of monoammonium malate (2014)
  • Author(s): Mita Hajime, Kouda Hikaru, Kanamaru Hiroshi, Nakai Takahiro, Hatae Kota, Turuyama Mami, and Kuwahar Ryusuke
  • Organizer: 14th Europian Astrobiology Conference
  • Place of Presentation: Edingburg, Scotoland
  • Year and Date: 2014-10-13 – 2014-10-16
• [Presentation] プロテノイドミクロスフェアとそれを形成するプロテノイド (2014)
  • Author(s): 香田輝,仲井貴弘,金丸博,鶴山真美,桑原裕典,三田肇
  • Organizer: プロテノイドミクロスフェアとそれを形成するプロテノイド 2014年度日本地球化学会年会
  • Place of Presentation: 富山大学、富山市
  • Year and Date: 2014-09-16 – 2014-09-18
• [Presentation] Chemical and physical properties of proteinoid microspheres (2014)
  • Author(s): MITA, Hajime, KANAMARU Hiroshi, KOUDA Hikaru, KUWAHARA Yusuke
  • Organizer: Origins 2014
  • Place of Presentation: Nara, Japan
  • Year and Date: 2014-07-06 – 2014-07-11
• [Presentation] 生命探査に向けたタンパク質加水分解方法の検討 (2014)
  • Author(s): 永沢恵理子、新垣汐里、豊田岐聡、山岸明彦、三田肇
  • Organizer: 生命の起原および進化学会 第39回学術講演会
  • Place of Presentation: 広島修道大学 (広島県広島市)
• [Presentation] 前生物的に生成するポリアミノ酸の化学構造解析 (2014)
  • Author(s): 香田輝、仲井貴弘、金丸博、三田肇
  • Organizer: 生命の起原および進化学会 第39回学術講演会
  • Place of Presentation: 広島修道大学 (広島県広島市)
• [Presentation] Characterization of proteinoid microsphere formations (2014)
  • Author(s): H. Kouda, T. Nakai, H. Kanamaru, K. Hatae, M. Turuyama, Y. Kuwahara, and H. Mita
  • Organizer: Japan-Taiwan Joint Workshop on Nanospace Materials
  • Place of Presentation: Fukuoka Institute of Technology (福岡県福岡市)
• [Presentation] Chemical and physical properties of proteinoid microspheres (2014)
  • Author(s): MITA, Hajime, KANAMARU Hiroshi, KOUDA Hikaru, KUWAHARA Yusuke
  • Organizer: Origins 2014 International Conference
  • Place of Presentation: Nara-ken ShinKokaido （奈良県奈良市）
• [Presentation] TANPOPO mission: Exposure experiments of organic compounds on the JEM, ISS. (2013)
  • Author(s): H. MITA, H. Hashimoto, M. Higashide, E. Imai, Y. Kawaguchi, H. Kawai, Y. Kawamoto, K. Knada, K. Kobayashi, K. Nakagawa, I, Narumi, K. Okudaira., M. Tabata, H. Yabuta, M. Yamashita, H. Yano, S. Yoshida, S. Yokobori, A. Yamagishi, and Tanpopo WG
  • Organizer: 13th Europian Workshop on Astrobilogy
  • Place of Presentation: University of Szczecin (Szczecin, Poland)
• [Presentation] Exposure Experiments of Organic Compounds on the JEM, ISS, in the Tanpopo Mission (2013)
  • Author(s): H. Mita, H. Hashimoto, M. Higashiide, E. Imai, Y. Kawaguchi, H. Kawai, Y. Kawamoto, K. Kanda, K. Kobayashi, K. Nakagawa, I. Narumi, K. Okudaira, M. Tabata, H. Yabuta, M. Yamashita, H. Yano, S. Yoshida, S. Yokobori, A. Yamagishi, and Tanpopo Working Group
  • Organizer: International Astrobiology Workshop 2013
  • Place of Presentation: JAXA/ISAS Sagamihara Campus (神奈川県相模原市)
• [Presentation] はやぶさ粒子の有機物分析などにより生命誕生の謎を探る (2013)
  • Author(s): 三田肇
  • Organizer: 日本表面技術協会１２８回講演大会
  • Place of Presentation: 福岡工業大学、福岡県福岡市
  • Invited
• [Remarks] 福岡工業大学三田研究室
  • URL: http://www.fit.ac.jp/~mita/index.html
• [Remarks] 福岡工業大学 三田肇
  • URL: http://www.fit.ac.jp/~mita/index.html