Structural analysis of primate blue-sensitive pigment by FTIR spectroscopy
| Project/Area Number |
25620011
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical chemistry
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
KANDORI Hideki 名古屋工業大学, 工学(系)研究科(研究院), 教授 (70202033)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 色覚 / 赤外分光 / 培養細胞 / 霊長類 / 水素結合 |
|---|
| Outline of Final Research Achievements |
Humans have two kinds of vision: twilight vision mediated by rhodopsin (Rh) and color vision achieved by three color pigments (blue, green and red). A common chromophore molecule, 11-cis retinal, is used to distinguish different colors in vision. While X-ray structure of Rh was determined, structural studies of color pigments lag far behind those of Rh. In 2010, we succeeded in structural analysis of monkey green and red sensitive pigments by use of low-temperature FTIR spectroscopy. In this project, we aimed at achieving the first structural analysis of blue pigment. By optimizing preparation and measuring conditions, we successfully obtained difference FTIR spectra of monkey blue at 77 K, which provided unique structural aspects to see blue lights. We are preparing the original paper, while I gave a keynote lecture in International Congress on Photobiology (Sep. 2014, Cordoba, Argentina).
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Report
(3 results)
Research Products
(103 results)
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[Journal Article] Structural basis for Na+ transport mechanism by a light-driven Na+ pump2015
Author(s)
H. E. Kato, K. Inoue, R. Abe-Yoshizumi, Y. Kato, H. Ono, M. Konno, S. Hososhima, T. Ishizuka, M. R. Hoque, H. Kunitomo, J. Ito, S. Yoshizawa, K. Yamashita, M. Takemoto, T. Nishizawa, R. Taniguchi, K. Kogure, A. D. Maturana, Y. Iino, H. Yawo, R. Ishitani, H. Kandori*, O. Nureki*
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Journal Title
Nature
Volume: 未定
Issue: 7550
Pages: 48-53
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 光といのち2014
Author(s)
神取秀樹
Organizer
岡崎市ホタル学校
Place of Presentation
岡崎
Year and Date
2014-06-07
Related Report
Invited
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[Presentation] The sodium pump rhodopsin discovered in ocean2014
Author(s)
K. Inoue, H. Ono, R. Abe-Yoshizumi, Y. Kato, H. Ito, Y. Soshizawa, K. Kogure, H. Kandori
Organizer
Gordon Research Conference on "Photosensory Receptors & Signal Transduction"
Place of Presentation
Lucca, Italy
Year and Date
2014-04-09
Related Report
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