| Project/Area Number |
25620075
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Chiba University |
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Principal Investigator |
ARAI TAKAYOSHI 千葉大学, 理学(系)研究科(研究院), 教授 (80272483)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 触媒 / 不斉合成 / 協奏機能 / 金属 / プロトン / 低分子量化合物 / カルボン酸 / ニトロ基 / 金属錯体 / 活性化 / 触媒設計・反応 / 錯体・有機金属触媒 / 触媒的不斉合成 / 配位子 / 低分子 / 反応場 / 反応機構 |
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| Outline of Final Research Achievements |
Originally developed Bis(imidazolidine)pyridine (PyBidine)-metal catalysts enabled various kinds of asymmetric reactions using oxidized small substrates. For the examples, PyBidine-Ni complex smoothly catalyzed asymmetric iodolactonization, nitro-Mannich reaction, and N,O-acetal formation. Chiral secondary amine-Cu complex, bis(oxazolidine)pyridine (PyBodine)-metal complex, and imidazolidine-consisting pincer complex were also prepared for showing the cooperative effect of metal-Lewis acids with proton. Based on the metal-carboxylate formation in the PyBidine-metal catalysis, a new tri-zinc complex was also developed for the asymmetric iodolactonization. Using these concert catalysts, intermolecular reaction using carbon dioxide and acetic acid was studied.
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