Survey and Development of Highly Active Catalysts for Environmentally Benign Synthesis of Optically Active 1,2-Diols
| Project/Area Number |
25620076
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
NISHIYAMA HISAO 名古屋大学, 工学(系)研究科(研究院), 教授 (40135421)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 有機合成 / 不斉合成 / 光学活性化合物 / 有機金属 / 触媒 / 合成化学 / 環境融和 / 不斉触媒 / 酸化反応 |
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| Outline of Final Research Achievements |
In organic synthesis, environmentally benign process has been pursued with no use of toxic materials and non precious metals. In this research, optically active 1,2-diols, which can be used as a starting materials for pharmaceutical and functional materials, can be synthesized by use of osmium salts. We examined asymmetric catalytic reaction with terminal alkenes and N,N,N-ligands. Using some of iron complexes and nitrogen ligands has been tried to obtain a small amount of epoxides and diol. On the other hand, the reaction through diboration followed by oxidation giving diols using chiral rhodium catalysts. Bis(oxazolnyl)phenyl-rhodium complex promoted successfully formation of diols from alkenes. In addition, 3-amino-1,2-diols were synthesized with the same Rh catalysts by using amido-, imide-, and carbamate-alkenes as substrates. Moreover, 1,2-disubstituted alkenes was tried by diboration to give the corresponding diols in good yields.
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Report
(4 results)
Research Products
(7 results)
