Synthetic studies on aconitine toward creation of new analgesics
| Project/Area Number |
25620088
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Waseda University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | アコニチン / 全合成研究 / 選択的合成 / モーヴァッサン還元 / アルドール反応 / 有機合成化学 / 全合成 / 立体選択的合成 |
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| Outline of Final Research Achievements |
Synthetic studies on aconitine have been deployed. Aconitine was devided to AEF rings and BCDE rings and synthetic routes of both compounds have been researched. At first, E ring moiety has been synthesized as a common part of them. An aldehyde derived from E ring was found to give aldol adducts with a precursor of A ring by using Lewis acid-mediated aldol reaction. Additionally, in studies of cyclization to obtain A ring, it was found that an olefin-attached alpha-diazoketone gave a cyclized compound via a diazo-attached intramolecular [3+2] adduct. On the other hand, E ring was coupled with C ring in accompany with the stereoselective construction of a quaternary carbon. D ring was constructed by ring closure metathesis to give CDE ring skeleton.
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Report
(4 results)
Research Products
(10 results)
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[Presentation] 全合成を短くする2014
Author(s)
細川 誠二郎
Organizer
平成26年度後期(秋季)有機合成化学講習会
Place of Presentation
東京
Year and Date
2014-11-20 – 2014-11-21
Related Report
Invited
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