| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Synthetic studies on aconitine have been deployed. Aconitine was devided to AEF rings and BCDE rings and synthetic routes of both compounds have been researched. At first, E ring moiety has been synthesized as a common part of them. An aldehyde derived from E ring was found to give aldol adducts with a precursor of A ring by using Lewis acid-mediated aldol reaction. Additionally, in studies of cyclization to obtain A ring, it was found that an olefin-attached alpha-diazoketone gave a cyclized compound via a diazo-attached intramolecular [3+2] adduct. On the other hand, E ring was coupled with C ring in accompany with the stereoselective construction of a quaternary carbon. D ring was constructed by ring closure metathesis to give CDE ring skeleton.
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