| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Glycolipids play important roles in cell processes such as bio-recognition on the cell membranes.Chemically, amphiphilic glycolipids can self-assemble into 3D architectures that are attractive smart hydrogels for biomolecular microarrays and dug delivery. Meanwhile, vinyl-contained glycolipid is potential monomer for the synthesis of glycopolymer, synthetic polymer with saccharide pendants, and has received considerable attention in the fields of material science and biomedicine. We have developed a reductive synthetic method towards glycolipid by the alcoholysis of the one-step preparable glycosyl donor,4,6-dibenzyloxy-1,3,5-triazin-2-yl glycosides under reductive conditions, without adding any acid catalysts. Through this reaction, glycosidic bonds between oligosaccharides and alcohols were constructed with the site specific activation at the reducing end under extremely mild reaction conditions, which had been impossible to carry out for a long time.
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