Establishment of Gel-Assmbly System with Metalloporphyrins and Ligands towards the Creation of Macroscopic Functions
Project/Area Number |
25620099
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Polymer chemistry
|
Research Institution | Osaka University |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 配位結合 / 金属ポルフィリン / アミノ酸 / 分子認識 / 高分子ヒドロゲル / 接着 / 可逆性 / pH応答性 / アポタンパク質 / 触媒反応 / 自己集積 / ホストーゲスト相互作用 / ポルフィリン / 金属錯体 / ヘム / 酸化反応 / ゲル / ヒドロゲル / マクロスケール / 金属 / 軸配位子 |
Outline of Final Research Achievements |
A gel assembly was formed via metal-ligand interactions using polyacrylamide modified with iron-porphyrin (Fe-Por) and L-histidine (L-His) moieties. The Fe-Por gel and the L-His gel immediately adhere to each other upon agitation in an 80 mM Tris-acetate buffer (pH 9.0). The assembly of the Fe-Por gel with L-His gel showed a pH dependency. The L-His gel formed an assembly with the Fe-Por gel at pH 9.0, however, no assembly of gels was observed at pH 2.0. Agitation in an aqueous solution containing an 60 mM L-His causes the assembly of the Fe-Por gel and L-His gel to dissociate, then washing with a fresh buffer reassembles the gel pieces. The binding and dissociation of the Fe-Por gel with the L-His gel are found to be reversible.
|
Report
(4 results)
Research Products
(39 results)