Development of optical indicators for reactive oxygen species

• Project/Area Number: 25620106
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Analytical chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: MORITOSHI Sato 東京大学, 総合文化研究科, 准教授 (00323501)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 活性酸素種 / 生物発光 / 生物発光タンパク質 / 細胞 / イメージング / プローブ / ルシフェラーゼ / 分泌

Outline of Final Research Achievements

Reactive oxygen species are involved in many diseases, such as cancer, diabetes and cardiovascular diseases. In this study we have developed novel optical probes to detect the dynamics of reactive oxygen species generated in living cells.