Design and synthesis of a molecular providing physical perturbation on living cell
| Project/Area Number |
25620119
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Analytical chemistry
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| Research Institution | Fukuoka University |
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Principal Investigator |
SHIOJI Kosei 福岡大学, 理学部, 准教授 (80291839)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 光異性化 / アゾベンゼン / 細胞 / ホスホニウム塩 |
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| Outline of Final Research Achievements |
Photomechanical effects of photochromic materials, which induce mechanical motions upon photoirradiation, have attracted a great deal of attention in recent years. Azo compounds are famous as dye and known for its photoisomerization by irradiation of UV light. We have synthesized an azo compound, having triphenylphosphonium salt to improve the subcellular localization ability, BODIPY as a fluorophore. The azo compound photoisomerized by visible light only. Furthermore, we observed the changes in cell morphological by effect of photoirradiation when introducing the compound into living cells.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Syntheses, Structures, and Properties of Biphosphinines Tethered Aromatic π-System2015
Author(s)
Noriyoshi Nagahora, Tamaki Ogawa, Maki Honda, Motomi Fujii, Hiroshi Tokumaru, Takahiro Sasamori, Kosei Shioji, Kentaro Okuma
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Journal Title
Chemistry Letters
Volume: 44
Issue: 5
Pages: 706-708
DOI
NAID
ISSN
0366-7022, 1348-0715
Related Report
Peer Reviewed / Open Access
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[Journal Article] Synthesis and Analysis of2015
Author(s)
Shuhei Toyofuku, Haruka Morita, Setsuko Ando, Kentaro Okuma, Noriyoshi Nagahora, Yasunori Aizawa, Hiroyuki Nakagawa, Kosei Shioji
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Journal Title
Peptide Science
Volume: 2014
Pages: 289-292
Related Report
Peer Reviewed / Open Access
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