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Design and synthesis of a molecular providing physical perturbation on living cell

Research Project

Project/Area Number 25620119
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Analytical chemistry
Research InstitutionFukuoka University

Principal Investigator

SHIOJI Kosei  福岡大学, 理学部, 准教授 (80291839)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords光異性化 / アゾベンゼン / 細胞 / ホスホニウム塩
Outline of Final Research Achievements

Photomechanical effects of photochromic materials, which induce mechanical motions upon photoirradiation, have attracted a great deal of attention in recent years. Azo compounds are famous as dye and known for its photoisomerization by irradiation of UV light. We have synthesized an azo compound, having triphenylphosphonium salt to improve the subcellular localization ability, BODIPY as a fluorophore. The azo compound photoisomerized by visible light only. Furthermore, we observed the changes in cell morphological by effect of photoirradiation when introducing the compound into living cells.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (19 results)

All 2015 2014 2013

All Journal Article (8 results) (of which Peer Reviewed: 7 results,  Open Access: 4 results) Presentation (11 results)

  • [Journal Article] Syntheses, Structures, and Properties of Biphosphinines Tethered Aromatic π-System2015

    • Author(s)
      Noriyoshi Nagahora, Tamaki Ogawa, Maki Honda, Motomi Fujii, Hiroshi Tokumaru, Takahiro Sasamori, Kosei Shioji, Kentaro Okuma
    • Journal Title

      Chemistry Letters

      Volume: 44 Issue: 5 Pages: 706-708

    • DOI

      10.1246/cl.150103

    • NAID

      130005067981

    • ISSN
      0366-7022, 1348-0715
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis and Analysis of2015

    • Author(s)
      Shuhei Toyofuku, Haruka Morita, Setsuko Ando, Kentaro Okuma, Noriyoshi Nagahora, Yasunori Aizawa, Hiroyuki Nakagawa, Kosei Shioji
    • Journal Title

      Peptide Science

      Volume: 2014 Pages: 289-292

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] One-pot synthesis of dibenzo[b,h][1,6]naphthyridines from 2-acetylaminobenzaldehyde: application to a fluorescent DNA-binding compound2014

    • Author(s)
      Kentaro Okuma *, Tomohiro Koga , Saori Ozaki , Yutaro Suzuki , Kenta Horigami , Noriyoshi Nagahora , Kosei Shioji , Masatora Fukuda and Masanobu Deshimaru
    • Journal Title

      Chemical Communications

      Volume: 50 Issue: 98 Pages: 15525-15528

    • DOI

      10.1039/c4cc07807a

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The First Formation of (1Z)-1-Alkylidene-1H-isobenzofuranium Amides and 1H-Inden-1-ones: Acid-Promoted 5-exo Cyclization and Hydration/Aldol Condensation Reactions of o-Ethynylbenzophenones2014

    • Author(s)
      Noriyoshi Nagahora, Tatsuya Wasano, Kazuhiro Nozaki, Tamaki Ogawa, Shuhei Nishijima, Daiki Motomatsu, Kosei Shioji andKentaro Okuma
    • Journal Title

      European Journal of Organic Chemistry

      Volume: 2014 Issue: 7 Pages: 1423-1430

    • DOI

      10.1002/ejoc.201301599

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel One-pot Synthesis of Polysubstituted Isocoumarins from Arynes and Trifluoroacetylated β-Diketones2014

    • Author(s)
      Kentaro Okuma, Koki Hirano, Yukiko Tanabe, Ryoichi Itoyama, Atsumi Miura, Noriyoshi Nagahora, Kosei Shioji
    • Journal Title

      Chemistry Letters

      Volume: 43 Issue: 4 Pages: 492-494

    • DOI

      10.1246/cl.131112

    • NAID

      130004868070

    • ISSN
      0366-7022, 1348-0715
    • Related Report
      2014 Annual Research Report
  • [Journal Article] Dramatic Effect of Atmosphere on Product Distribution from Steady-State Photolysis of Triarylphosphines2014

    • Author(s)
      Shinro Yasui, Yuya Ogawa, Kosei Shioji, Masaaki Mishima, Shoko Yamazaki
    • Journal Title

      Bulletin of the Chemical Society of Japan

      Volume: 87 Issue: 9 Pages: 988-996

    • DOI

      10.1246/bcsj.20140100

    • NAID

      130004153314

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-pot Synthesis of 2,3-Benzodiazepines from Arynes and beta-Diketones2013

    • Author(s)
      Okuma K, Tanabe Y, Itoyama R, Nagahora N, Shioji K
    • Journal Title

      Chemistry Letters

      Volume: 42 Issue: 10 Pages: 1260-1262

    • DOI

      10.1246/cl.130580

    • NAID

      10031201331

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Atmosphere-Controlled Dual Reactivity of Triarylphosphine in the Photoexcited State: P-C Bond Cleavage vs Electron Transfer2013

    • Author(s)
      Yasui, S.; Ogawa, Y.; Shioji, K.; Yamazaki, S.
    • Journal Title

      Chem. Lett.

      Volume: 42 Issue: 12 Pages: 1478-1480

    • DOI

      10.1246/cl.130748

    • NAID

      130004867836

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] ハロゲンおよびスルホン酸エステル置換基を有するホスフィニン類の合成2015

    • Author(s)
      長洞記嘉, 徳丸裕士, 塩路幸生, 大熊健太郎
    • Organizer
      日本化学会 第95春季年会
    • Place of Presentation
      日本大学 理工学部船橋キャンパス/薬学部
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] キラルな 4,4’-アリール-1,1’-ビ-2-ナフトール誘導体の合成2015

    • Author(s)
      大熊健太郎, 堀上健太, 塩路幸生, 長洞記嘉
    • Organizer
      日本化学会 第95春季年会
    • Place of Presentation
      日本大学 理工学部船橋キャンパス/薬学部
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞内分子モーターを指向したアゾベンゼン誘導体の合成とその光特性2015

    • Author(s)
      尾崎雅司, 中川裕之, 長洞記嘉, 大熊健太 郎, 塩路幸生
    • Organizer
      日本化学会 第95春季年会
    • Place of Presentation
      日本大学 理工学部船橋キャンパス/薬学部
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脂質修飾を受けるペプチドの細胞内動態解析プローブの合成と分析2015

    • Author(s)
      塩路幸生, 豊福修平, 安東勢津子, 長洞記嘉, 大熊 健太郎, 中川裕之, 相澤康則
    • Organizer
      日本化学会 第95春季年会
    • Place of Presentation
      日本大学 理工学部船橋キャンパス/薬学部
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 分子内にホスホニウム塩とアゾベンゼンを有する化合物の合成とその光特性2014

    • Author(s)
      尾崎雅司, 長洞記嘉, 大熊健太郎, 塩路幸生
    • Organizer
      第41回有機典型元素化学討論会
    • Place of Presentation
      宇部市文化会館
    • Year and Date
      2014-11-27 – 2014-11-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Synthesis and analysis of intracellular molecular dynamics of novel fluorescent prove having myristoylated peptide2014

    • Author(s)
      Shuhei Toyofuku, Haruka Morita, Setsuko Ando, Kentaro Okuma, Noriyoshi Nagahora, Yasunori Aizawa, Hiroyuki Nakagawa, Kosei Shioji
    • Organizer
      第51回ペプチド討論会
    • Place of Presentation
      徳島大学大塚講堂
    • Year and Date
      2014-10-22 – 2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] アラインとβ-ジカルボニル化合物を用いた2,3-ベンゾジアゼピン誘導体の合成2014

    • Author(s)
      田邊 裕紀子・長洞 記嘉・塩路 幸生・大熊 健太郎
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 2-ベンゾチオおよび2-ベンゾセレノピリリウム塩類縁体の合成2014

    • Author(s)
      長洞 記嘉・藤井 元美・塩路 幸生・大熊 健太郎
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 共役系スペーサーで連結したホスフィニン二量体の合成と性質の解明(2014

    • Author(s)
      長洞 記嘉・小川 環樹・塩路 幸生・大熊 健太郎
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Research-status Report
  • [Presentation] チオフェンコンと求電子試薬との反応: Wagner-Meerwein転位2014

    • Author(s)
      松井 宏幸・長洞 記嘉・塩路 幸生・大熊 健太郎
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 過酸化水素を捕捉する DNA 局在化蛍光プローブの合成と性質2013

    • Author(s)
      揚村雄・中川裕之・長洞記嘉・大熊健太郎・塩路幸生
    • Organizer
      第 40 回 有機典型元素化学討論会
    • Place of Presentation
      近畿大学 11 月ホール
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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