Research Project
Grant-in-Aid for Challenging Exploratory Research
Human genome project has revealed that the mechanism of gene expression is much more complicated than that we have believed to date. This project focused on the novel RNA-diagnosis system for understanding the detailed mechanism of gene expression where RNAs play crucial roles. As results, we innovated the following systems: (1)Fluorescent-RNA-detection system to detect specific RNA in homogeneous physiological condition. The system was successfully applied to detect unusual splicing products of the muscular dystrophy. (2)Fluorescent-RNA-detection system to detect RNA-protein complexes such as telomerses and RNA-induced silencing complex (RISC). The system successfully detected telomerase in fixed cells and RISC in living cells. The system can be applied to the development of the novel curing methods of various diseases such as cancers.
All 2015 2014 2013
All Journal Article (4 results) (of which Peer Reviewed: 4 results, Open Access: 3 results, Acknowledgement Compliant: 2 results) Presentation (30 results) (of which Invited: 1 results) Book (2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)
Bioorg Med Chem
Volume: 22 Issue: 3 Pages: 1003-1007
10.1016/j.bmc.2013.12.044
Photochemistry and Photobiology
Volume: 90 Issue: 3 Pages: 716-722
10.1111/php.12232
Bioorganic & Medicinal Chemistry Letters
Volume: 3 Issue: 21 Pages: 5875-5828
10.1016/j.bmcl.2013.08.100
Bioscience, Biotechnology, and Biochemistry,
Volume: 77 Pages: 1117-1119
10031177609
