Elucidation of anticancer activity of organic/metallic hybrid polymer

Research Project

Project/Area Number	25620166
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Organic and hybrid materials
Research Institution	National Institute for Materials Science
Principal Investigator	HIGUCHI Masayoshi 独立行政法人物質・材料研究機構, 高分子材料ユニット, グループリーダー (80306852)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	有機／金属ハイブリッドポリマー / 抗がん特性
Outline of Final Research Achievements	We found organic-metallic hybrid polymer binds with DNA chains strongly due to the ionic interaction before. In this project I tried to reveal (1) the detailed interaction of organic-metallic hybrid polymer with DNA chains and (2) anticancer activity of organic-metallic hybrid polymer. The achievements are following. We successfully prepared organic-metallic hybrid polymers with different chain length and investigated the cytotoxicity to cancer cells. Interestingly, the organic-metallic hybrid polymer with the stronger binding affinity to DNA showed the higher anticancer activity.

Report

(3 results)