Elucidation of anticancer activity of organic/metallic hybrid polymer
| Project/Area Number |
25620166
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Organic and hybrid materials
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
HIGUCHI Masayoshi 独立行政法人物質・材料研究機構, 高分子材料ユニット, グループリーダー (80306852)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 有機／金属ハイブリッドポリマー / 抗がん特性 |
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| Outline of Final Research Achievements |
We found organic-metallic hybrid polymer binds with DNA chains strongly due to the ionic interaction before. In this project I tried to reveal (1) the detailed interaction of organic-metallic hybrid polymer with DNA chains and (2) anticancer activity of organic-metallic hybrid polymer. The achievements are following.
We successfully prepared organic-metallic hybrid polymers with different chain length and investigated the cytotoxicity to cancer cells. Interestingly, the organic-metallic hybrid polymer with the stronger binding affinity to DNA showed the higher anticancer activity.
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Report
(3 results)
Research Products
(4 results)
