Development of Cardiac Patch of Silk Fibroin Controlled The Bioabsorbable Property
Project/Area Number |
25620169
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Polymer/Textile materials
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Research Institution | Tokyo University of Agriculture and Technology |
Principal Investigator |
Asakura Tetsuo 東京農工大学, 工学(系)研究科(研究院), 名誉教授 (30139208)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 高分子材料 / 医療用パッチ / 絹 / ポリウレタン / エレクトロスピニング / トランスジェニック高機能化絹 / 医薬用パッチ |
Outline of Final Research Achievements |
Several kinds of functional silk fibroins containing the amino acid sequences suitable for biomaterials were produced by transgenic silkworms. The composite materials with these silk fibroins and segmented polyurethane were prepared with electrospinning technique. The cardiac patch and artificial vascular grafts with very small diameter were developed. Animal implantation experiments using these composite materials showed these materials have excellent operability for implantation and excellent properties for the purpose.
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Report
(4 results)
Research Products
(106 results)
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[Journal Article] Rapid endothelialization and thin luminal layers in vascular grafts using silk fibroin2016
Author(s)
Yamamoto, S., Okamoto, H., Haga, M., Shigematsu, K., Miyata, T., Watanabe, T., Ogawa, Y., Takagib, Y., Asakura, T.
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Journal Title
Journal of Materials Chemistry B
Volume: 4
Issue: 5
Pages: 938-946
DOI
Related Report
Peer Reviewed
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[Journal Article] Intermolecular Packing in B. mori Silk Fibroin: Multinuclear NMR Study of the Model Peptide (Ala-Gly)15 Defines a Heterogeneous Antiparallel Antipolar Mode of Assembly in the Silk II Form2015
Author(s)
Asakura, T., Ohata, T., Kametani S., Okushita, K., Yazawa, K., Nishiyama, Y., Nishimura, K., Aoki, A., Suzuki, F., Kaji, H., Anne S. Ulrich, and Mike P. Williamson
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Journal Title
Macromolecules
Volume: 48
Issue: 1
Pages: 28-36
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Effect of fibroin sponge coating on in vivo performance of knitted silk small diameter vascular grafts2015
Author(s)
Fukayama, T., Ozai, Y., Shimokawadoko, H., Derya Aytemiz, Tanaka, R., Machida, N., Asakura, T.
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Journal Title
Organogenesis
Volume: 11
Issue: 3
Pages: 137-151
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Structural Transition of <i>Bombyx mori</i> Liquid Silk Studied with Vibrational Circular Dichroism Spectroscopy2015
Author(s)
Morisaku, T., Arai, S., Konno, K., Suzuki, Y., Asakura, T., Yui, H.
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Journal Title
Analytical Sciences
Volume: 31
Issue: 8
Pages: 763-768
DOI
NAID
ISSN
0910-6340, 1348-2246
Related Report
Peer Reviewed / Open Access
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[Journal Article] Structural Determination of the Tandem Repeat Motif in Samia cynthia ricini Liquid Silk by Solution NMR2015
Author(s)
Suzuki, Y, Kawanishi, S., Yamazaki, T., Aoki, A., Saito, H., Asakura, T.
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Journal Title
Macromolecules
Volume: 48
Issue: 18
Pages: 6574-6579
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] In vitro and in vivo Evaluation of Hemocompatibility of Silk Fibroin Based Artificial Vascular Grafts2014
Author(s)
Derya Aytemiz, Suzuki, Y., Shindo, T., Saotome, T., Tanaka, R., Asakura, T.
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Journal Title
International Journal of Chemistry
Volume: 6
Issue: 2
Pages: 1-14
DOI
Related Report
Peer Reviewed
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[Journal Article] Recombinant silk fibroin incorporated celladhesive sequences produced by transgenic silkworm as a possible candidate for use in vascular graft2014
Author(s)
Asakura, T., Isozaki, M., Saotome, T., Tatematsu, K., Sezutsu, H., Kuwabara, N., Nakazawa, Y.
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Journal Title
Journal of Materials Chemistry B
Volume: 2
Issue: 42
Pages: 7375-7383
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Silk fibroin-based scaffolds for bone regeneration2013
Author(s)
Kuboyama N, Kiba H, Arai K, Uchida R, Tanimoto Y, Bhawal UK, Abiko Y, Miyamoto S, Knight D, Asakura T, Nishiyama N.
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Journal Title
J Biomed Mater Res B Appl Biomater
Volume: Vol.101
Issue: 2
Pages: 295-302
DOI
Related Report
Peer Reviewed
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[Journal Article] Synthesis and Characterization of Water-Soluble Silk Peptides and Recombinant Silk Protein Containing Polyalanine, the Integrin Binding Site, and Two Glutamic Acids at Each Terminal Site as a Possible Candidate for Use in Bone Repair Materials2013
Author(s)
Asakura, T., Suzuki, Y., Nagano, A., Knight, D.P., Kamiya, M., Demura, M.
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Journal Title
Biomacromolecules
Volume: 14
Issue: 10
Pages: 3731-3741
DOI
Related Report
Peer Reviewed
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