Movement of blood cell components measured by Optical Coherence Tomography
| Project/Area Number |
25630057
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fluid engineering
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| Research Institution | Kansai University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SEKI Junji 関西大学, 先端科学技術推進機構, 非常勤研究員 (20163082)
MAKINO Masato 山形大学大学院, 理工学研究科, 助教 (10649172)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 光コヒーレンス断層法 / 血球 |
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| Outline of Final Research Achievements |
This study was aimed to develop an optical coherence tomography (OCT) system which can measure the spatial distribution of blood cell components in microvessels. First we developed a time-domain OCT system using a super luminescent diode (SLD), the spatial resolution of which was about 12 um in water. Polystyrene particles with 10 um diameter floating in a tube with inner diameter less than 1 mm could be observed by this OCT system. Next, the OCT system was improved to a frequency domain OCT by replacing the light source with a swept source laser with broader band width and high repetition rate, resulting in a higher spatial resolution as well as a higher-speed tomography. This improvement enabled the measurement of positions of particles flowing through sub-millimeter tubes. Further the segregation behavior of blood cell components was numerically simulated using a two-dimensional model, and its mechanism was examined by comparing the results with experimental observations.
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Report
(3 results)
Research Products
(51 results)
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[Journal Article] Venular valves and retrograde perfusion2014
Author(s)
Tomiyasu Koyama, Masako Sugihara-Seki, Tadahiro Sasajima, Sinsuke Kikuchi
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Journal Title
Oxygen Transoprt to Tissue XXXVI, Advances in Experimental Medicine and Biology
Volume: 812
Pages: 317-323
DOI
ISBN
9781493905836, 9781493906208
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Lateral migration of a spherical particle in square channel flows2014
Author(s)
Sugihara-Seki, M., Nakagawa, N., Kase, A., Otomo, R., Makino, M., Itano, T.
Organizer
APS 67th Annual Meeting, Division of Fluid Dynamics
Place of Presentation
San Francisco(USA)
Year and Date
2014-11-23
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