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Investigation of dynamical behaviors of targeted microbubbles for medical applications

Research Project

Project/Area Number 25630079
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Dynamics/Control
Research InstitutionKeio University

Principal Investigator

SUGIURA TOSHIHIKO  慶應義塾大学, 理工学部, 教授 (70265932)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords振動工学 / 超音波 / マイクロバブル / 非線形動力学 / モード局在化 / 非線形振動 / キャビテーション / 分子動力学計算
Outline of Final Research Achievements

With a view to clarifying dynamical behaviors of targeted microbubbles and their medical applications, this research tried to clarify nonlinear dynamical behaviors of an insonified bubble analytically, numerically and experimentally, and further investigated dynamical behaviors of a bubble cluster experimentally. Findings of this research include effects of polymer membranes of a bubble on its nonlinear or nonspherical oscillations, effects of a nearby wall surface on subharmonic resonances of a bubble, effects of attachment of a bubble to a wall on its oscillations, dynamical behaviors of a bubble close to a wall and micro-jet generation around the bubble, oscillation mode localization caused by nonlinear interaction between bubbles, and features of translational motion of a bubble cluster showing volume oscillation.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2014 2013 Other

All Presentation (14 results) (of which Int'l Joint Research: 2 results) Remarks (1 results)

  • [Presentation] Numerical analysis of microbubble deformation near a high-viscous liquid in ultrasound field2016

    • Author(s)
      Kengo Mori, Toshihiko Sugiura
    • Organizer
      The 9th International Conference in Multiphase Flow
    • Place of Presentation
      Florence (Italy)
    • Year and Date
      2016-05-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spherical anb translational dynamics of a collapsing cavitation bubble cluster2016

    • Author(s)
      Naohiro Sugita, Toshihiko Sugiura
    • Organizer
      The 21th European Symposium on Ultrasound Contrast Agent
    • Place of Presentation
      Rotterdam (The Netherlands)
    • Year and Date
      2016-01-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 周期的に変動する圧力場において球形クラスター気泡にはたらく第二ビヤクネス力2015

    • Author(s)
      杉田直広、杉浦壽彦
    • Organizer
      第36回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県・つくば市)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 超音波照射下における2つの造影剤気泡の挙動に関する非線形解析2015

    • Author(s)
      山下貴司,杉田直広,杉浦壽彦
    • Organizer
      日本機械学会 関東学生会 第54回学生員卒業研究発表講演会
    • Place of Presentation
      横浜国立大学(神奈川県横浜市)
    • Year and Date
      2015-03-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 超音波照射下における壁面近傍のマイクロバブルの振動に関する数値解析2015

    • Author(s)
      森健悟,杉浦壽彦,大宮啓太
    • Organizer
      日本機械学会関東学生会第54回学生員卒業研究発表講演会
    • Place of Presentation
      横浜国立大学(神奈川県横浜市)
    • Year and Date
      2015-03-20
    • Related Report
      2014 Research-status Report
  • [Presentation] A numerical study on the natural frequency of a microbubble bound to a surface2015

    • Author(s)
      Naohiro Sugita, Toshihiko Sugiura
    • Organizer
      The 20th European Symposium on Ultrasound Contrast Imaging
    • Place of Presentation
      Rotterdam (The Netherlands)
    • Year and Date
      2015-01-22 – 2015-01-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Nonlinear Localization in Two Gas bubbles in an Ultrasound Field2014

    • Author(s)
      Naohiro Sugita, Toshihiko Sugiura
    • Organizer
      The 1st International conference on ultrasonic-based applications: from analysis to synthesis
    • Place of Presentation
      Costa da Caparica (Portugal)
    • Year and Date
      2014-09-15 – 2014-09-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 音響連成した二つのマイクロバブルにおける非線形ノーマルモード2014

    • Author(s)
      杉田直広,杉浦壽彦
    • Organizer
      日本機械学会 機械力学・計測制御部門 Dynamics & Design Conference 2014
    • Place of Presentation
      上智大学(東京都千代田区)
    • Year and Date
      2014-08-26 – 2014-08-29
    • Related Report
      2014 Research-status Report
  • [Presentation] Numerical Study on Nonlinear Oscillation and Translation of an Insonified Microbubble2014

    • Author(s)
      Keita Omiya, Hiroki Kubo, Kei Terada, Toshihiko Sugiura
    • Organizer
      The 19th European Symposium on Ultrasound Contrast Imaging
    • Place of Presentation
      Rotterdam, The Netherlands
    • Related Report
      2013 Research-status Report
  • [Presentation] Effects of Hard-Spring Characteristics of Radial Oscillations on Parametrically Excited Surface Oscillations of a Lipid-Coated Bubble2013

    • Author(s)
      Naohiro Sugita, Mitsutoshi Fujiwara, Toshihiko Sugiura
    • Organizer
      8th International Conference on Multiphase Flow
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] Effects of Microbubble Interaction on Occurrence of Subharmonics2013

    • Author(s)
      Shoma Kanazawa, Akira Tsuruoka, Toshihiko Sugiura
    • Organizer
      IEEE 2013 Joint UFFC, EFTF, and PFM Symposium
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2013 Research-status Report
  • [Presentation] 分数調波の発生におけるマイクロバブルの非線形相互作用の影響2013

    • Author(s)
      金澤翔真,鶴岡聖,杉浦壽彦
    • Organizer
      日本混相流学会 混相流シンポジウム2013
    • Place of Presentation
      信州大学(長野市)
    • Related Report
      2013 Research-status Report
  • [Presentation] C-CUP法を用いた超音波照射下におけるマイクロバブルの非線形振動解析2013

    • Author(s)
      大宮啓太,久保弘樹,杉浦壽彦
    • Organizer
      日本混相流学会 混相流シンポジウム2013
    • Place of Presentation
      信州大学(長野)
    • Related Report
      2013 Research-status Report
  • [Presentation] 境界要素法を用いた超音波照射下における微小気泡の非線形応答解析2013

    • Author(s)
      杉田直広,杉浦壽彦
    • Organizer
      日本機械学会 Dynamics and Design Conference 2013
    • Place of Presentation
      九州産業大学(福岡)
    • Related Report
      2013 Research-status Report
  • [Remarks] 杉浦研究室ホームページ

    • URL

      http://www.dynamics.mech.keio.ac.jp/research/bubble/index.html

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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