| Project/Area Number |
25630095
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Intelligent mechanics/Mechanical systems
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| Research Institution | Kagawa University |
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Principal Investigator |
TERAO Kyohei 香川大学, 工学部, 准教授 (80467448)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 分子操作 / ＤＮＡ / 光ピンセット / ナノマイクロ加工 / ＤＮＡナノテクノロジー |
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| Outline of Final Research Achievements |
This project aims at the development of the technique to connect DNA nanodevices to micron-size devices, including MEMS or IC, on a single chip using giant DNA molecules as molecular wires, which have the size of 2 nm in width and over 100 micrometers in length.
For the demonstration of the DNA molecular wiring, we fabricated the micropillar electrodes covered with gold on a glass substrate, on which a DNA wire is immobilized and connected electrically. The side walls of the pillars were successfully covered with gold, which are also used for chemical modification to improve the adhesion between DNA and the pillars. For the manipulation of each single DNA molecules, we developed optically-driven microstructures and evaluated their characteristics. We demonstrated the extension of single yeast chromosomal DNA molecules of Mbp size by catching them between 2 optically-driven microstructures and translocating them in aqueous situation.
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