Formation of artificial nano-cells for in-situ TEM observation of material reaction in the water
| Project/Area Number |
25630269
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical properties of metals/Metal-base materials
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | バイオマテリアル / 水 / TEM / リポソーム / DPPC / リン脂質二重層膜 / コレステロール / ＴＥＭ / ＤＰＰＣ |
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| Outline of Final Research Achievements |
Liposome reinforced by adding cholesterol was synthesized using the dipalmitoylphosphatidylcholine (DPPC). Phase stability of the phospholipid bilayers was examined by FTIR spectroscopy. The reinforced liposomes filled with ultrapure water or physiological saline were observed by the conventional TEM equipped with a mass spectrometer. It was confirmed that the liposomes filled with water or saline solution were stable in the vacuum at room temperature. However、 during electron irradiation、 water molecules escaped gradually、 and a single crystal of rock salt precipitated in the liposome. Similar phenomenon was also observed in the case of cesium iodide solution.
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Report
(4 results)
Research Products
(8 results)
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[Presentation] 抗原抗体反応の電顕観察2014
Author(s)
川下温, 春本高志, 村上明一, 東隆親, 石黒孝
Organizer
2014 5th Biomedical Interface Workshop
Place of Presentation
沖縄県石垣市商工会ホール
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