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Induction of differentiation directivity of human induced pluripotent stem cells through cell migration

Research Project

Project/Area Number 25630377
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Biofunction/Bioprocess
Research InstitutionOsaka University

Principal Investigator

KINO-OKA Masahiro  大阪大学, 工学(系)研究科(研究院), 教授 (40234314)

Project Period (FY) 2013-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywordsバイオ生産プロセス / 再生医療 / ヒトiPS細胞 / 分化制御 / 生物・生体工学 / 細胞・組織 / iPS細胞 / 文化方向性制御
Research Abstract

In order to apply human induced pluripotent stem cells (hiPSCs) for industrial application including regenerative medicine, elucidating the mechanisms underlying behaviour is required for regulating hiPSC fate determination. In this study, we focused on the initial fate decision of hiPSCs during the two-dimensional cultures with feeder cells. In addition, we proposed culture strategy designed dealing with determination of hiPSC fates. These studies provide a novel approach for expansion of hiPSCs through regulation of cell-cell and cell-substrate interactions.

Report

(2 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (13 results)

All 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) Book (2 results)

  • [Journal Article] Switching between self-renewal and lineage commitment of human induced pluripotent stem cells via cell-substrate and cell-cell interactions on a dendrimer-immobilized surface2014

    • Author(s)
      Kim M-H, Kino-oka M.
    • Journal Title

      Biomaterials

      Volume: 35 Issue: 22 Pages: 5670-5678

    • DOI

      10.1016/j.biomaterials.2014.03.085

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] ヒト iPS細胞の継代培養における未分化状態からの逸脱現象の解明2013

    • Author(s)
      松原佳史,増田英里,伊賀朋世,金美海,紀ノ岡正博
    • Organizer
      第65回日本生物工学会大会
    • Place of Presentation
      広島国際会議場,広島県
    • Year and Date
      2013-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] デンドリマー培養面を用いたヒトiPS細胞の継代培養における未分化維持能の解析2013

    • Author(s)
      金美海,紀ノ岡正博
    • Organizer
      第65回日本生物工学会大会
    • Place of Presentation
      広島国際会議場,広島県
    • Year and Date
      2013-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト幹細胞の遊走阻害による未分化・分化の制御2013

    • Author(s)
      守随恵理,金美海,紀ノ岡正博
    • Organizer
      化学工学会第45回秋季大会
    • Place of Presentation
      岡山大学津島(東)キャンパス,岡山県
    • Year and Date
      2013-09-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Coordination of Cell-Cell Interactions and Cell-Substrate Interactions by Altering Migration is required for Regulating Fate2013

    • Author(s)
      Mee-Hae Kim and Masahiro Kino-oka
    • Organizer
      International Society for Stem Cell Research 10th Annual Meeting (ISSCR)
    • Place of Presentation
      Boston Convention & Exhibition Center, Boston, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Characterization of Derivation from Undifferentiation in Colonies of Human Induced Pluripotent Stem Cells based on Kinetic Analysis2013

    • Author(s)
      Mee-Hae Kim, Masuda Eri, and Masahiro Kino-oka
    • Organizer
      International Society for Stem Cell Research 10th Annual Meeting (ISSCR)
    • Place of Presentation
      Boston Convention & Exhibition Center, Boston, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Coordination of Cell-Cell Interactions and Cell-Substrate Interactions by Altering Migration is required for Regulating Fate Decision of Human Induced Pluripotent Stem Cells2013

    • Author(s)
      Mee-Hae Kim and Masahiro Kino-oka
    • Organizer
      International Society for Stem Cell Research 10th Annual Meeting (ISSCR)
    • Place of Presentation
      Boston Convention & Exhibition Center (Boston, USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Characterization of Derivation from Undifferentiation in Colonies of Human Induced Pluripotent Stem Cells based on Kinetic Analysis2013

    • Author(s)
      Mee-Hae Kim, Masuda Eri and Masahiro Kino-oka
    • Organizer
      International Society for Stem Cell Research 10th Annual Meeting (ISSCR)
    • Place of Presentation
      Boston Convention & Exhibition Center (Boston, USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒト幹細胞の遊走阻害による未分化・分化の制御2013

    • Author(s)
      守随 恵理,金 美海,紀ノ岡 正博
    • Organizer
      化学工学会第45回秋季大会
    • Place of Presentation
      岡山大学津島東キャンパス(岡山県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒトiPS細胞の継代培養における未分化状態からの逸脱現象の解明2013

    • Author(s)
      松原 佳史, 増田 英里, 伊賀 朋世, 金 美海, 紀ノ岡 正博
    • Organizer
      第65回日本生物工学会大会
    • Place of Presentation
      広島国際会議場(広島県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] デンドリマー培養面を用いたヒトiPS細胞の継代培養における未分化維持能の解析2013

    • Author(s)
      金 美海, 紀ノ岡 正博
    • Organizer
      第65回日本生物工学会大会
    • Place of Presentation
      広島国際会議場(広島県)
    • Related Report
      2013 Annual Research Report
  • [Book] デンドリマー培養面を利用したヒトiPS細胞の未分化維持(バイオマテリアル-生体材料,2013,Vol.31)2013

    • Author(s)
      金美海,紀ノ岡正博
    • Publisher
      日本医学館
    • Related Report
      2013 Final Research Report
  • [Book] バイオマテリアル-生体材料-2013

    • Author(s)
      金 美海,紀ノ岡正博
    • Total Pages
      66
    • Publisher
      日本医学館
    • Related Report
      2013 Annual Research Report

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Published: 2014-07-25   Modified: 2016-11-25  

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