Research Project
Grant-in-Aid for Challenging Exploratory Research
The NMDA receptor is associated with the modulation of synaptic transmission in the central nervous system and is related not only to the regulation of higher brain functions such as learning and memory but also to the etiology of various psychiatrical and neurological disorders at the level of the whole animal. The activation of NMDA receptors requires the binding of glutamate as well as the coagonist D-serine. In this project, we have found that the effects of D-serine on NMDA receptors in the CA1 region of the mouse hippocampal slice are different between synaptic and extrasynaptic NMDA receptors. Furthermore, we have obtained preliminary data suggesting the possibility that there is some abnormality in synaptic plasticity in the knockout mouse lacking serine racemase that produces D-serine in the brain.
All 2014 2013 Other
All Journal Article (3 results) (of which Peer Reviewed: 3 results, Open Access: 3 results, Acknowledgement Compliant: 1 results) Presentation (5 results) Book (5 results) Remarks (2 results)
J Neurosci
Volume: 34(17) Issue: 17 Pages: 5927-5937
10.1523/jneurosci.1621-13.2014
European Journal of Neuroscience
Volume: 40 Issue: 8 Pages: 3136-3146
10.1111/ejn.12682
J. Biol. Chem.
Volume: 288 Issue: 48 Pages: 34906-34919
10.1074/jbc.m113.504050
http://www.ims.u-tokyo.ac.jp/NeuronalNetwork/Neuronal_Network/Index.html
