Searching for brain regions involved in individual recognition using medaka fish

• Project/Area Number: 25640006
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology / General neuroscience
• Research Institution: The University of Tokyo
• Principal Investigator: TAKEUCHI Hideaki 東京大学, 理学(系)研究科(研究院), 助教 (00376534)
• Co-Investigator(Renkei-kenkyūsha): KAMEI Yasuhiro 基礎生物学研究所, 光学解析室, 特任准教授 (70372563)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 社会性 / 個体認知 / 社会行動 / 脳 / 神経系 / GnRH / 社会脳

Outline of Final Research Achievements

Medaka females can discriminate between socially-familiarized and unfamiliar males and prefer to mate with the former. Here we showed that GnRH3 neurons have a central role in the mate preference for the familiar males. In addition, we established a gene manipulation technique for site-specific Cre/loxP recombination in the telencephalon and a novel behavioral system to investigate an ability of individual recognition.

Research Products

• [Journal Article] An Essential Role of the Arginine Vasotocin System in Mate-Guarding Behaviors in Triadic Relationships of Medaka Fish (Oryzias latipes). (2015)
  • Author(s): Yokoi S, Okuyama T, Kamei Y, Naruse K, Taniguchi Y, Ansai S, Kinoshita M, Young LJ, Takemori N, Kubo T, Takeuchi H
  • Journal Title: PLoS Genetics Volume: なし Issue: 2 Pages: e1005009-e1005009
  • DOI: 10.1371/journal.pgen.1005009
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Genetic control of startle behavior in medaka fish (2014)
  • Author(s): Tsuboko S, Kimura T, Shinya M, Suehiro Y, Okuyama T, Shimada A, Takeda H, Naruse K, Kubo T, Takeuchi H
  • Journal Title: PLoS one Volume: 9 Issue: 11 Pages: e112527-e112527
  • DOI: 10.1371/journal.pone.0112527
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Analysis of mechanism underlying brain growth accompanied by neurogenesis using medaka fish (Oryzias latipes) (2014)
  • Author(s): Yasuko Isoe, Teruhiro Okuyama, Masahito Hoki, Yuji Suehiro, Genki Yamagishi,Kiyoshi Naruse, Masato Kinoshita, Yasuhiro Kamei, Shigenori Nonaka Atushi Shimizu, Takeo Kubo, Hideaki Takeuchi
  • Organizer: Neuroscience 2014/ SfN(北米神経学会)
  • Place of Presentation: アメリカ・ワシントンD.C.
  • Year and Date: 2014-11-17
• [Presentation] Analysis of mechanism underlying brain growth accompanied by neurogenesis using medaka fish (Oryzias latipes) (2014)
  • Author(s): Yasuko Isoe, Teruhiro Okuyama, Masahito Hoki, Yuji Suehiro, Genki Yamagishi,Kiyoshi Naruse, Masato Kinoshita, Yasuhiro Kamei, Shigenori Nonaka Atushi Shimizu, Takeo Kubo, Hideaki Takeuchi
  • Organizer: Neuro2014 / The 36th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 名古屋
  • Year and Date: 2014-09-09
• [Presentation] Analysis of mechanism underlying brain growth accompanied by neurogenesis using medaka fish (Oryzias latipes) (2014)
  • Author(s): Yasuko Isoe, Teruhiro Okuyama, Masahito Hoki, Yuji Suehiro, Genki Yamagishi,Kiyoshi Naruse, Masato Kinoshita, Yasuhiro Kamei, Shigenori Nonaka Atushi Shimizu, Takeo Kubo, Hideaki Takeuchi
  • Organizer: 2014 International Congress of Neuroethology/The Japanese Society for comparative Physiology and Biochemistry
  • Place of Presentation: 札幌
  • Year and Date: 2014-07-29
• [Presentation] Searching for genes affecting visually-evoked startle response properties with inbred strains of Medaka (Oryzias latipes) -- Genetically Affected Escape Modes in Solitary and Collective States of Medaka Fish (2014)
  • Author(s): Tsuboko S, Kimura T, Shinya M, Suehiro Y, Okuyama T, Shimada A, Takeda H, Naruse K, Kubo T, Takeuchi H
  • Organizer: 2014 International Congress of Neuroethology/The Japanese Society for comparative Physiology and Biochemistry
  • Place of Presentation: 札幌
  • Year and Date: 2014-07-28
• [Presentation] Analysis of mechanism underlying brain growth accompanied by neurogenesis using medaka fish (Oryzias latipes) (2014)
  • Author(s): Yasuko Isoe, Teruhiro Okuyama, Masahito Hoki, Yuji Suehiro, Genki Yamagishi,Kiyoshi Naruse, Masato Kinoshita, Yasuhiro Kamei, Shigenori Nonaka Atushi Shimizu, Takeo Kubo, Hideaki Takeuchi
  • Organizer: 2nd Strategic Meeting for Medaka Research
  • Place of Presentation: セビリア・スペイン
  • Year and Date: 2014-04-10 – 2014-04-12
• [Presentation] Searching for genes affecting visually-evoked startle response properties with medaka inbred strains (2014)
  • Author(s): Tsuboko S, Kimura T, Shinya M, Suehiro Y, Okuyama T, Shimada A, Takeda H, Naruse K, Kubo T, Takeuchi H
  • Organizer: 2nd Strategic Meeting for Medaka Research
  • Place of Presentation: セビリア・スペイン
  • Year and Date: 2014-04-10 – 2014-04-12
• [Presentation] Behavioral polymorphism in medaka strains: genetic factor matters? (2014)
  • Author(s): Mu-Yun Wang, Takeo Kubo and Hideaki Takeuchi
  • Organizer: 2nd Strategic Meeting for Medaka Research
  • Place of Presentation: セビリア・スペイン
  • Year and Date: 2014-04-10 – 2014-04-12
• [Presentation] Proximate and ultimate causes of socially-regulated mating preference in medaka fish (2014)
  • Author(s): Hideaki Takeuchi
  • Organizer: 2nd Strategic Meeting for Medaka Research
  • Place of Presentation: セビリア・スペイン
  • Year and Date: 2014-04-10
  • Invited
• [Presentation] メダカを用いた配偶者防衛行動の神経基盤解析 (2013)
  • Author(s): 横井佐織、奥山輝大、久保健雄、竹内秀明
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
• [Book] 動物行動の分子生物学 (2014)
  • Author(s): 竹内秀明
  • Total Pages: 27
  • Publisher: 裳華房
• [Remarks]
  • URL: http://www.s.u-tokyo.ac.jp/ja/press/4416/
• [Remarks] メダカはずっとそばにいてくれた異性に恋をする
  • URL: http://www.s.u-tokyo.ac.jp/ja/press/2014/01.html