Regeneration of motor and sensory neurons in zebrafish spinal cord after injury.
| Project/Area Number |
25640008
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Kanazawa University |
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Principal Investigator |
KATO Satoru 金沢大学, 健康増進科学センター, 研究協力員 (10019614)
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| Co-Investigator(Kenkyū-buntansha) |
SUGITANI Kayo 金沢大学, 保健学系, 助教 (20162258)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脊髄損傷 / 感覚神経 / 運動神経 / 再生 / 細胞生存 / zebrafish / Sox2 / IGF-Ⅰ / 軸索再生 / 神経軸索再生 / ゼブラフィッシュ |
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| Outline of Final Research Achievements |
In the transectioned zebrafish spinal cord model, upper motor neurons in the brain can survive and regrow their axon after spinal cord injury. The regenerative axons from upper motor neurons in the brain were accompanied with upregulation of IGF-1 expression in their soma. While lower appeared to be neurons were newly synthesized from ependymal cells nearly located near in the central canal of the spinal cord. Sensory neuron in the dorsal root ganglion can survive but not regrow their axons after spinal cord injury.
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Report
(3 results)
Research Products
(18 results)
