Analysis of signal dynamics mediated by AMPK subfamily in synapse maturation
| Project/Area Number |
25640009
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 分子細胞神経科学 / アクティブゾーン / リン酸化 / シナプス / SAD / CAST / AMPK / 細胞極性 / 神経伝達物質 |
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| Outline of Final Research Achievements |
Accumulating evidence suggests that serine /threonine kinase AMPK subfamily regulate neuronal polarization such as axon/dendrite formation. Here, we show that 1) MARK and AMPK1 are biochemically localized and expressed in the nerve terminals, in particular synaptic vesicles and active zone fractions; 2) phosphorylation of CAST regulates release of neurotransmitter from the active zone; and 3) SAD family may be involved in cell death. These results suggest that AMPK family member regulate not only neuronal polarization but also neurotransmitter release from the nerve terminals.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Identification, expression and characterization of rat isoforms of the serum response factor (SRF) coactivator MKL1.2013
Author(s)
Ishikawa, M., Shiota, J., Ishibashi, Y., Hakamata, T., Shoji, S., Fukuchi, M., Tsuda, M., Shirao, T., Sekino, Y., Ohtsuka, T., Baraban, J.M., Tabuchi, A.
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Journal Title
FEBS Open Bio.
Volume: 3
Issue: 1
Pages: 387-393
DOI
Related Report
Peer Reviewed
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