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Association between mitochondrial quality control and Parkinson's disease by FKBP38

Research Project

Project/Area Number 25640013
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Neurophysiology / General neuroscience
Research InstitutionKyushu University

Principal Investigator

SHIRANE Michiko  九州大学, 生体防御医学研究所, 准教授 (90398082)

Project Period (FY) 2013-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords病態脳科学 / ミトコンドリア
Research Abstract

Shh signaling pathway is conserved among animals and has pivotal roles in embryonic development, in the maintenance of adult stem cells, and in cancer. FKBP38 has been shown to act in a cell-autonomous manner to prevent inappropriate activation of the Shh pathway. It has remained unclear, however, how FKBP38 suppresses Shh signaling.
With the use of a proteomics approach to the discovery of proteins that regulate Shh signaling in association with FKBP38, we have now identified ANKMY2 as a molecule that interacts with FKBP38. Depletion or overexpression of ANKMY2 resulted in down- and up-regulation of Shh signaling, respectively, in mouse embryonic fibroblasts. Furthermore, combined depletion of both FKBP38 and ANKMY2 attenuated Shh signaling in these cells, suggesting that ANKMY2 acts downstream of FKBP38 to activate the Shh signaling pathway. Our findings thus indicate that the FKBP38-ANKMY2 axis plays a key role in regulation of Shh signaling in vivo.

Report

(2 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (12 results)

All 2014 2013

All Journal Article (8 results) (of which Peer Reviewed: 3 results) Presentation (4 results) (of which Invited: 2 results)

  • [Journal Article] Identification and characterization of a neuron-specific isoform of protrudin2014

    • Author(s)
      Ohnishi, T., Shirane, M., Hashimoto, Y., Saita, S., and Nakayama, K. I.
    • Journal Title

      Genes Cells

      Volume: 19 Pages: 97-111

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mitochondria : FKBP38 and mitochondrial degradation2014

    • Author(s)
      Shirane-Kitsuji, M. and Nakayama, K. I.
    • Journal Title

      Int. J. Bioc. Cell Biol

      Volume: 51 Pages: 19-22

    • Related Report
      2013 Final Research Report
  • [Journal Article] Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia2014

    • Author(s)
      Hashimoto, Y., Shirane, M., Matsuzaki, F., Saita, S. Ohnishi, T., and Nakayama, K. I.
    • Journal Title

      J. Biol. Chem

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] ミトコンドリア品質管理機構と神経機能制御2014

    • Author(s)
      白根道子
    • Journal Title

      「生化学」ミニレビュー

      Volume: (in press)

    • NAID

      40020200989

    • Related Report
      2013 Final Research Report
  • [Journal Article] Identification and characterization of a neuron-specific isoform of protrudin.2014

    • Author(s)
      Ohnishi, T., *Shirane, M., Hashimoto, Y., Saita, S., and Nakayama, K. I.
    • Journal Title

      Genes Cells

      Volume: 19 Issue: 2 Pages: 97-111

    • DOI

      10.1111/gtc.12109

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondria: FKBP38 and mitochondrial degradation.2014

    • Author(s)
      Shirane-Kitsuji, M. and Nakayama, K. I.
    • Journal Title

      Int. J. Bioc. Cell Biol.

      Volume: 51 Pages: 19-22

    • DOI

      10.1016/j.biocel.2014.03.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia.2014

    • Author(s)
      Hashimoto, Y., * Shirane, M., Matsuzaki, F., Saita, S. Ohnishi, T., and Nakayama, K. I.
    • Journal Title

      J. Biol. Chem.

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] マイトファジーにおける選択的タンパク質脱出の発見と機構解析2013

    • Author(s)
      細田將太郎、白根道子、中山敬一
    • Journal Title

      細胞工学

      Volume: 32 Pages: 582-583

    • Related Report
      2013 Final Research Report
  • [Presentation] Escape of proteins from mitochondria upon mitophagy2013

    • Author(s)
      Shirane, M., Saita, S., and Nakayama, KI
    • Organizer
      International Symposium on Mitochondria 2013
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulatory mechanism and function of neuronal endomembrane system US-Japan Brain Research Collaborative Program2013

    • Author(s)
      Shirane, M
    • Organizer
      Current Trends and Future Direction of Synaptic Plasticity Research
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulatory mechanism and function of neuronal endomembrane system2013

    • Author(s)
      Shirane, M.
    • Organizer
      US-Japan Brain Research Collaborative Program
    • Place of Presentation
      Seattle, WA, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Escape of proteins from mitochondria upon mitophagy2013

    • Author(s)
      Shirane, M., Saita, S., and Nakayama, KI.
    • Organizer
      International Symposium on Mitochondria 2013
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2014-07-25   Modified: 2016-11-25  

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