| Project/Area Number |
25640015
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
MIZUNO Hidenobu 国立遺伝学研究所, 個体遺伝研究系, 助教 (00567159)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | バレル / 樹状突起 / 体性感覚野 / 大脳皮質 / 2光子イメージング / 二光子顕微鏡 / マウス / 電気選考法 / マウス遺伝学 / タイムラプスイメージング |
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| Outline of Final Research Achievements |
In this study, we analyzed the mechanism for neuronal circuit refinement in developing cerebral cortex, using the thalamocortical circuits in the barrel cortex as a model system.
We developed the “Supernova system” to label a sparse population of neurons in the brain and a method for in vivo time lapse imaging of developing barrel cortex. By using them, we found that cortical dendrites are highly motile during refinement of thalamocortical circuits, and that these dendritic dynamics are regulated by NMDA-type glutamate receptor functions.
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