| Project/Area Number |
25640019
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
NUMAKAWA Tadahiro 独立行政法人国立精神・神経医療研究センター, 神経研究所 疾病研究第三部, 客員研究員 (40425690)
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| Co-Investigator(Renkei-kenkyūsha) |
HASHIDO Kazuo 独立行政法人国立精神・神経医療研究センター, 神経研究所 ラジオアイソトープ管理室, 室長 (70270650)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | microRNA / 神経伝達 / 神経栄養因子 / 脳神経疾患 / 神経科学 / マイクロRNA / エクソソーム |
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| Outline of Final Research Achievements |
It has been suggested that changed blood level of miRs is beneficial biomarker of diseases including brain dysfunction. In this study, we examined function of brain-specific miRs in the neuronal and glial system, and a possibility of miR transmission among cells. We found that upregulation of several brain-specific miRs in exosome released from cultured cortical neurons after application of BDNF, which is essential growth factor for neural function in the central nervous system neurons. On the other hand, bFGF, which is involved in glial survival and differentiation, increased the levels of miR-134. Furthermore, we found that the bFGF/miR-134 system is important for maturation of astroglia, including upregulation of glutamate transporter.
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