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Effect of Mg-L-threonate on alpha synuclein Tg mice

Research Project

Project/Area Number 25640028
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Nerve anatomy/Neuropathology
Research InstitutionShinshu University

Principal Investigator

OYANAGI Kiyomitsu  信州大学, 医学部, 特任教授 (00134958)

Co-Investigator(Kenkyū-buntansha) SUZUKI Emi  信州大学, 医学部, 研究員 (80623686)
FUJITA Masayo  公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 研究員 (90415539)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsパーキンソン病 / アルファシヌクレイン遺伝子組換えマウス / マグネシウム / マグネシウム-L-スレオネート / アルファシヌクレイン / マグネシウム-L-スレオネート / 黒質 / ドパミン神経細胞 / 定量
Outline of Final Research Achievements

Magnesium-L-threonate (Mg-L-Th: It had been reported that the oral intake of Mg-L-Th increased the concentration of Mg in the cerebrospinal fluid by 10 to 20%. Mg-L-Th was purchased from two companies (A and B).) was administered to the alpha-synuclein transgenic (aSyn tg) mice, which are considered to be a model of Parkinson disease, and the wild type (WT) mice. Gait of aSyn tg mice, such as width of forefoot and hind foot, was not improved by Mg-L-Th administration. In addition, frequency of jumping to the cage wall of aSyn tg mice was not decreased. But the concentration of dopamine in the neostriatum, which was lower in aSyn tg mice than WT mice, was increased significantly in aSyn tg mice by Mg-L-Th from A company.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2015 2014 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Remarks (3 results)

  • [Journal Article] Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis2015

    • Author(s)
      Kaneko M, Noguchi T, Ikegami S, Sakurai T, Kakita A, Toyoshima Y, Kambe T, Yamada M, Inden M, Hara H, Oyanagi K, Inuzuka T, Takahashi H, Hozumi I.
    • Journal Title

      J Neurosci Res

      Volume: 93(2) Issue: 2 Pages: 370-9

    • DOI

      10.1002/jnr.23491

    • NAID

      120007100194

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mannitol infusion immediately after reperfusion suppresses the development of focal cortical infarction after temporary cerebral ischemia in gerbils.2014

    • Author(s)
      Ito U, Hakamata Y, Watabe K, Oyanagi K.
    • Journal Title

      Neuropathology

      Volume: 34 Issue: 4 Pages: 360-369

    • DOI

      10.1111/neup.12113

    • NAID

      120007100195

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Remarks] 信州大学医学部神経難病学講座

    • URL

      http://www.shinshu-u.ac.jp/faculty/medicine/department/medical_science/course/course35.php

    • Related Report
      2014 Annual Research Report
  • [Remarks] 信州大学医学部神経難病学講座

    • URL

      http://www.shinshu-u.ac.jp/faculty/medicine/chair/i-nanbyou/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 信州大学神経難病学講座

    • URL

      http://www.shinshu-u.ac.jp/faculty/medicine/chair/i-nanbyou/

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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