Effect of Mg-L-threonate on alpha synuclein Tg mice

• Project/Area Number: 25640028
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Shinshu University
• Principal Investigator: OYANAGI Kiyomitsu 信州大学, 医学部, 特任教授 (00134958)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Emi 信州大学, 医学部, 研究員 (80623686) ; FUJITA Masayo 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 研究員 (90415539)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: パーキンソン病 / アルファシヌクレイン遺伝子組換えマウス / マグネシウム / マグネシウム-L-スレオネート / アルファシヌクレイン / マグネシウム-Ｌ-スレオネート / 黒質 / ドパミン神経細胞 / 定量

Outline of Final Research Achievements

Magnesium-L-threonate (Mg-L-Th: It had been reported that the oral intake of Mg-L-Th increased the concentration of Mg in the cerebrospinal fluid by 10 to 20%. Mg-L-Th was purchased from two companies (A and B).) was administered to the alpha-synuclein transgenic (aSyn tg) mice, which are considered to be a model of Parkinson disease, and the wild type (WT) mice. Gait of aSyn tg mice, such as width of forefoot and hind foot, was not improved by Mg-L-Th administration. In addition, frequency of jumping to the cage wall of aSyn tg mice was not decreased. But the concentration of dopamine in the neostriatum, which was lower in aSyn tg mice than WT mice, was increased significantly in aSyn tg mice by Mg-L-Th from A company.

Research Products

• [Journal Article] Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis (2015)
  • Author(s): Kaneko M, Noguchi T, Ikegami S, Sakurai T, Kakita A, Toyoshima Y, Kambe T, Yamada M, Inden M, Hara H, Oyanagi K, Inuzuka T, Takahashi H, Hozumi I.
  • Journal Title: J Neurosci Res Volume: 93(2) Issue: 2 Pages: 370-9
  • DOI: 10.1002/jnr.23491
  • NAID: 120007100194
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Mannitol infusion immediately after reperfusion suppresses the development of focal cortical infarction after temporary cerebral ischemia in gerbils. (2014)
  • Author(s): Ito U, Hakamata Y, Watabe K, Oyanagi K.
  • Journal Title: Neuropathology Volume: 34 Issue: 4 Pages: 360-369
  • DOI: 10.1111/neup.12113
  • NAID: 120007100195
  • Peer Reviewed / Open Access
• [Remarks] 信州大学医学部神経難病学講座
  • URL: http://www.shinshu-u.ac.jp/faculty/medicine/department/medical_science/course/course35.php
• [Remarks] 信州大学医学部神経難病学講座
  • URL: http://www.shinshu-u.ac.jp/faculty/medicine/chair/i-nanbyou/
• [Remarks] 信州大学神経難病学講座
  • URL: http://www.shinshu-u.ac.jp/faculty/medicine/chair/i-nanbyou/