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Mechanisms of brain formation regulated by birth

Research Project

Project/Area Number 25640032
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurochemistry/Neuropharmacology
Research InstitutionKanazawa University

Principal Investigator

KAWASAKI Hiroshi  金沢大学, 脳・肝インターフェイスメディシン研究センター, 教授 (50303904)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords神経細胞成熟 / 出生 / 神経成熟 / 脳・神経
Outline of Final Research Achievements

Using the cerebral cortex of embryonic and neonatal mice, microarray experiments were performed to identify the molecules whose expression levels changed before and after birth. Using in utero electroporation, loss- and gain-of-function studies were carried out, and we identified molecules that negatively regulated dendritic maturation. Furthermore, we found that the migration of immature neurons was also affected, suggesting that dendritic maturation should occur appropriate time point during development. Our results uncovered a novel regulatory mechanisms of neuronal maturation soon after birth.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (34 results)

All 2015 2014 2013 2012 Other

All Journal Article (9 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 3 results,  Open Access: 3 results) Presentation (19 results) (of which Invited: 4 results) Book (3 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Spatio-temporal regulation of the formation of the somatosensory system2015

    • Author(s)
      Kawasaki H.
    • Journal Title

      Development, Growth & Differentiation

      Volume: 57 Issue: 3 Pages: 193-199

    • DOI

      10.1111/dgd.12208

    • NAID

      120005613962

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Classic cadherins mediate selective intracortical circuit formation in the mouse neocortex2015

    • Author(s)
      Wakimoto M., Sehara K., Ebisu H., Hoshiba Y., Tsunoda S., Ichikawa Y. and Kawasaki H.
    • Journal Title

      Cerebral Cortex

      Volume: 25 Issue: 10 Pages: 3535-3546

    • DOI

      10.1093/cercor/bhu197

    • NAID

      120005704523

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] フェレットを用いた高等哺乳動物の脳神経医学研究2015

    • Author(s)
      河崎洋志
    • Journal Title

      生体の科学

      Volume: 66 Pages: 1-6

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Establishment of an experimental ferret ocular hypertension model for the analysis of central visual pathway damage2014

    • Author(s)
      Fujishiro T., Kawasaki H., Aihara M., Saeki T., Yamagishi R., Atarashi T., Mayama C. and Araie M.
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 6501-6501

    • DOI

      10.1038/srep06501

    • NAID

      120005764197

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular investigations of the brain of higher mammals using gyrencephalic carnivore ferrets2014

    • Author(s)
      Kawasaki H.
    • Journal Title

      Neuroscience Research

      Volume: 86 Pages: 59-65

    • DOI

      10.1016/j.neures.2014.06.006

    • NAID

      120005537870

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The development of suckling behavior of neonatal mice is regulated by birth.2014

    • Author(s)
      Toda T. and Kawasaki H.
    • Journal Title

      Molecular Brain

      Volume: 7 Issue: 1 Pages: 8-8

    • DOI

      10.1186/1756-6606-7-8

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 脳神経系の形成制御機構の解明とその医学的応用2014

    • Author(s)
      河崎洋志
    • Journal Title

      金沢大学十全医学会雑誌

      Volume: 123 Pages: 34-34

    • Related Report
      2014 Annual Research Report
    • Open Access
  • [Journal Article] Birth regulates the initiation of sensory map formation through serotonin signaling.2013

    • Author(s)
      Toda T., Homma D., Tokuoka H., Hayakawa I., Sugimoto Y., Ichinose H. and Kawasaki H
    • Journal Title

      Developmental Cell

      Volume: 27 Issue: 1 Pages: 32-46

    • DOI

      10.1016/j.devcel.2013.09.002

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] FoxP2 is a parvocellular-specific transcription factor in the visual thalamus of monkeys and ferrets.2012

    • Author(s)
      Iwai L., Ohashi Y. van der List D., Usrey W. M., Miyashita Y., Kawasaki H.
    • Journal Title

      Cerebral Cortex

      Volume: - Issue: 9 Pages: 2204-2212

    • DOI

      10.1093/cercor/bhs207

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] フェレットとマウスにおけるFoxP2陽性網膜神経節細胞の個性解析2015

    • Author(s)
      佐藤千尋、河崎洋志
    • Organizer
      第92回日本生理学会大会・第120回日本解剖学会
    • Place of Presentation
      神戸国際会議場、神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] The role of Foxp2 in the thalamic pattern formation during development2015

    • Author(s)
      Ebisu, H., Kawasaki H.
    • Organizer
      第8回神経発生討論会
    • Place of Presentation
      九州大学、博多
    • Year and Date
      2015-03-19 – 2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 大脳皮質神経細胞における樹状突起の成熟抑制機構の解析2015

    • Author(s)
      干場義生、河崎洋志
    • Organizer
      金沢大学脳肝インターフェースメディシン研究センターシンポジウム2015
    • Place of Presentation
      KKR金沢、金沢
    • Year and Date
      2015-03-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 神経回路形成における軸索ガイダンス分子Draxinの機能2015

    • Author(s)
      新明洋平、河崎洋志
    • Organizer
      金沢大学脳肝インターフェースメディシン研究センターシンポジウム2015
    • Place of Presentation
      KKR金沢、金沢
    • Year and Date
      2015-03-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 視床パターン形成におけるFoxp2の機能解析2015

    • Author(s)
      蛭子はるか、河崎洋志
    • Organizer
      金沢大学脳肝インターフェースメディシン研究センターシンポジウム2015
    • Place of Presentation
      KKR金沢、金沢
    • Year and Date
      2015-03-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 感覚神経回路形成における出生の意義2014

    • Author(s)
      河崎洋志
    • Organizer
      生理研研究会「シナプス・神経ネットワークの機能ダイナミクス」
    • Place of Presentation
      生理学研究所、岡崎
    • Year and Date
      2014-12-02 – 2014-12-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 大脳皮質神経細胞の成熟抑制機構の解析2014

    • Author(s)
      干場義生、戸田智久、Wegner M., 田中弘文、柳茂、河崎洋志
    • Organizer
      国立遺伝学研究所研究会「哺乳類脳の機能的神経回路の構築メカニズム」
    • Place of Presentation
      国立遺伝学研究所、三島
    • Year and Date
      2014-12-01 – 2014-12-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] The molecular mechanism of thalamic pattern formation during development2014

    • Author(s)
      Ebisu H., Iwai L., Momoi T., Kawasaki H.
    • Organizer
      国立遺伝学研究所研究会「哺乳類脳の機能的神経回路の構築メカニズム」
    • Place of Presentation
      国立遺伝学研究所、三島
    • Year and Date
      2014-12-01 – 2014-12-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] The molecular mechanism of thalamic pattern formation during development2014

    • Author(s)
      Ebisu H., Iwai L., Momoi T., Kawasaki H.
    • Organizer
      44th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] The role of Sox11 in neuronal maturation in the mouse cerebral cortex2014

    • Author(s)
      Hoshiba Y., Toda T., Wegner M., Yanagi S., Tanaka H., Kawasaki H.
    • Organizer
      44th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウス大脳皮質の神経細胞成熟過程におけるSox11の機能解析2014

    • Author(s)
      干場義生、戸田智久、河崎洋志
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脳神経系の形成過程における出生の役割2014

    • Author(s)
      河崎洋志
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Birth regulates sensory map formation during development2014

    • Author(s)
      Hiroshi Kawasaki
    • Organizer
      第47回日本発生生物学会
    • Place of Presentation
      ウインク愛知、名古屋
    • Year and Date
      2014-05-27 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 出生による脳神経系発達の制御メカニズム2014

    • Author(s)
      河崎洋志
    • Organizer
      第12回GPCR研究会
    • Place of Presentation
      日本科学未来館、東京
    • Year and Date
      2014-05-09 – 2014-05-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] フェレットを用いた高等哺乳動物の脳神経系の分子遺伝学的解析

    • Author(s)
      河崎洋志
    • Organizer
      第60回日本実験動物学会総会
    • Place of Presentation
      つくば国際会議場、つくば市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 子宮内電気穿孔法を用いたフェレット大脳皮質の形成過程解析

    • Author(s)
      河崎洋志、戸田智久、岩井玲奈
    • Organizer
      第46回日本発生生物学会
    • Place of Presentation
      くにびきメッセ、松江市
    • Related Report
      2013 Research-status Report
  • [Presentation] 感覚神経形成の時空間的制御メカニズム

    • Author(s)
      河崎洋志
    • Organizer
      第36回日本神経科学学会
    • Place of Presentation
      国立京都国際会館、京都市
    • Related Report
      2013 Research-status Report
  • [Presentation] Birth regulates the initiation of sensory map formation through serotonin signaling

    • Author(s)
      戸田智久、本間大悟、徳岡宏文、早川格、一瀬宏、河崎洋志
    • Organizer
      包括脳夏のワークショップ
    • Place of Presentation
      名古屋国際会議場、名古屋市
    • Related Report
      2013 Research-status Report
  • [Presentation] Inner fiber layer-like structures revealed with in utero electroporation in ferrets

    • Author(s)
      Kawasaki H., Toda T., Iwai L., Tanno K.
    • Organizer
      Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego Convension Center, San Diego, USA
    • Related Report
      2013 Research-status Report
  • [Book] Electroporation Methods and Neuroscience2014

    • Author(s)
      Kawasaki H. (Saito T. ed.)
    • Total Pages
      9
    • Publisher
      Springer Publishers
    • Related Report
      2014 Annual Research Report
  • [Book] 脳神経系の発生・再生の融合的新展開2014

    • Author(s)
      河崎洋志(井村裕夫、高橋淳監修)
    • Total Pages
      6
    • Publisher
      診断と治療社
    • Related Report
      2014 Annual Research Report
  • [Book] 分子脳科学2014

    • Author(s)
      河崎洋志(三品昌美編)
    • Total Pages
      7
    • Publisher
      化学同人
    • Related Report
      2014 Annual Research Report
  • [Remarks] 河崎研究室

    • URL

      http://square.umin.ac.jp/top/kawasaki/Welcome.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 研究室のホームページ

    • URL

      http://square.umin.ac.jp/top/kawasaki/Welcome.html

    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 高等哺乳動物を用いた新規脳疾患モデル動物2015

    • Inventor(s)
      河崎洋志、桝田宏輔
    • Industrial Property Rights Holder
      河崎洋志、桝田宏輔
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-006388
    • Filing Date
      2015-01-16
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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