Modification of neuronal identity specification in the developing brain
| Project/Area Number |
25640039
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurochemistry/Neuropharmacology
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
ARAMAKI MICHIHIKO 慶應義塾大学, 医学部, 助教 (20338099)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | 大脳新皮質 / 神経細胞 / 層特異性 / 転写因子 / 発生・分化 / 神経科学 / 大脳皮質 / 抑制性神経細胞 |
|---|
| Outline of Final Research Achievements |
In this study, we found that overexpression of a certain gene could modify the neuronal identity in the developing cerebral neocortex. In the upper cortical plate neurons, a mutually repressive mechanism exists between two kinds of transcription factors, Brn2 and Rorb, and the established expression of Brn1/2 and Rorb specifies those neurons into layer 2-3 and layer 4, respectively, during cortical plate maturation.
|
Report
(4 results)
Research Products
(18 results)
