| Project/Area Number |
25640041
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOMURA Michio 京都大学, 大学院教育学研究科, 准教授 (60399011)
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| Co-Investigator(Renkei-kenkyūsha) |
IWAMOTO Kazuya 東京大学, 医学部付属病院, 准教授 (40342753)
BUNTOU Miki 東京大学, 医学部付属病院, 助教 (00597221)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 衝動性 / セロトニントランスポータ遺伝子多型 / DNA メチル化 / セロトニントランスポーター遺伝子多型 / DNAメチル化 / ゲノム・エピゲノム / 遺伝子多型 / セロトニン / 認知機能 / 急性ストレス |
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| Outline of Final Research Achievements |
We examined effects of serotonin transporter (5-HTTLPR) genotypes on motor regulatory process, as observed during a Go/Nogo punishment feedback task. 5-HTT gene-linked promoter polymorphisms were analyzed by using lymphocytes from 60 healthy Japanese volunteers. Impulsivity was defined as the number of commission errors (responding when one should not) made during a Go/Nogo task. We found that the s/s group made fewer impulsive responses, under aversive conditions for committing such errors, compared to those in the s/l group, without affecting motor inhibition, suggesting that 5-HTTLPRs do not directly affect the behavioral regulatory process itself, but may instead exert an effect on the evaluation of potential risk. The results also indicate that under such aversive conditions, decreased expression of 5-HTT may promote motor inhibitory control.Then we found 10% DNA methylation ratio in downstream of CPG island of 5-HTTLPR in buccal cells which is less than 30% in blood samples.
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