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Serotonin transporter gene-linked promotor-polymorphism and DNA methylation involved in personalized impulsivity

Research Project

Project/Area Number 25640041
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurochemistry/Neuropharmacology
Research InstitutionKurume University

Principal Investigator

NOMURA Yasuyuki  久留米大学, 医学部, 教授 (00034041)

Co-Investigator(Kenkyū-buntansha) NOMURA Michio  京都大学, 大学院教育学研究科, 准教授 (60399011)
Co-Investigator(Renkei-kenkyūsha) IWAMOTO Kazuya  東京大学, 医学部付属病院, 准教授 (40342753)
BUNTOU Miki  東京大学, 医学部付属病院, 助教 (00597221)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords衝動性 / セロトニントランスポータ遺伝子多型 / DNA メチル化 / セロトニントランスポーター遺伝子多型 / DNAメチル化 / ゲノム・エピゲノム / 遺伝子多型 / セロトニン / 認知機能 / 急性ストレス
Outline of Final Research Achievements

We examined effects of serotonin transporter (5-HTTLPR) genotypes on motor regulatory process, as observed during a Go/Nogo punishment feedback task. 5-HTT gene-linked promoter polymorphisms were analyzed by using lymphocytes from 60 healthy Japanese volunteers. Impulsivity was defined as the number of commission errors (responding when one should not) made during a Go/Nogo task. We found that the s/s group made fewer impulsive responses, under aversive conditions for committing such errors, compared to those in the s/l group, without affecting motor inhibition, suggesting that 5-HTTLPRs do not directly affect the behavioral regulatory process itself, but may instead exert an effect on the evaluation of potential risk. The results also indicate that under such aversive conditions, decreased expression of 5-HTT may promote motor inhibitory control.Then we found 10% DNA methylation ratio in downstream of CPG island of 5-HTTLPR in buccal cells which is less than 30% in blood samples.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (4 results) Book (4 results)

  • [Journal Article] Modulation of empathy in the left ventrolateral prefrontal cortex facilitates altruistic behavior: An fNIRS study.2015

    • Author(s)
      Himichi, T., & Nomura, M.
    • Journal Title

      Journal of Integrative Neuroscience

      Volume: in press Issue: 02 Pages: 1-16

    • DOI

      10.1142/s0219635215500120

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Involvement of serotonin transporter gene polymorphism (5-HTT) in impulsive behavior in the Japanese population2015

    • Author(s)
      Nomura M., Kaneko M., Okuma Y., Nomura J., Kusumi I., Koyama T. and Nomura Y.
    • Journal Title

      PLos One

      Volume: 10

    • NAID

      120005745671

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative emotions impacts lateral prefrontal cortex activation during Theory of Mind : An fNIRS study2015

    • Author(s)
      Himichi T., Fujita H. and Nomura M.
    • Journal Title

      Social Neuroscience

      Volume: なし Pages: 1-11

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of a nicotinic receptor gene polymorphism with spontaneous eyeblink rates.2015

    • Author(s)
      Nakano, T., Kuriyama, C., Himichi, T., & Nomura, M.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 8658-8658

    • DOI

      10.1038/srep08658

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 日米で食薬区分の異なるメラトニンのインターネットを介した個人輸入における安全性情報の比較2014

    • Author(s)
      大塚邦子、野村靖幸、内田直樹、安原一、小林真一
    • Journal Title

      社会薬学

      Volume: 印刷中

    • NAID

      130005092170

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Does the right inferior parietal lobule correlate with task-unrelated thoughts? : A transcranial direct current2015

    • Author(s)
      Nomura M., Kadono Y. and Kajimura S.
    • Organizer
      12th International Conference on Alzheimer's and Parkinson's Diseases
    • Place of Presentation
      Nice, France
    • Year and Date
      2015-03-18 – 2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Relationship between racial essentialism disposition, emotion and genetics2015

    • Author(s)
      Fujita H., Himichi T. and Nomura M.
    • Organizer
      16th Annual Meeting of Society for Personality and Social Psychology
    • Place of Presentation
      Long Beach, California, USA
    • Year and Date
      2015-02-26 – 2015-02-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of 5HT2A receptor gene polymorphism on lateral prefrontal cortex activation during empathy2014

    • Author(s)
      Himichi T., Kaneko M., Nomura J., Okuma Y., Nomura Y. and Nomura M.
    • Organizer
      17th World Congress of Psychophysiology
    • Place of Presentation
      International Conference Center Hiroshima, Hiroshima, Japan
    • Year and Date
      2014-09-23 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effects of oxytocin receptor gene polymorphism and psychological stress on cognitive inferring of other’s mind.2014

    • Author(s)
      2. Himichi, T., Kaneko, M., Nomura, J., Okuma, Y., Nomura, Y., Nomura, M.
    • Organizer
      The 15th Annual Meeting of Society for Personality and Social Psychology
    • Place of Presentation
      San Diego
    • Related Report
      2013 Research-status Report
  • [Book] 発達科学ハンドブック、第8巻脳の発達科学2015

    • Author(s)
      野村理朗
    • Publisher
      新曜社
    • Related Report
      2014 Annual Research Report
  • [Book] Handbook of Cultural Neuroscience: Cultural Neuroscience and Health2015

    • Author(s)
      Nomura M.
    • Publisher
      Oxford University Press
    • Related Report
      2014 Annual Research Report
  • [Book] 脳とこころ 唐沢かおり(編)「社会心理学-心と社会をつなぐ知の統合-」2014

    • Author(s)
      野村理朗
    • Total Pages
      15
    • Publisher
      北大路書房
    • Related Report
      2013 Research-status Report
  • [Book] くすりと健康2013

    • Author(s)
      野村靖幸
    • Total Pages
      247
    • Publisher
      薬事日報社
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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