Functional analysis of breast cancer regulating gene Pla2g4c and its application in treatment
| Project/Area Number |
25640058
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | Pla2g4c / 乳がん |
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| Research Abstract |
I recently found that the tumor size is small and the incidence of breast cancer is reduced in phospholipase A2 group IVc (Pla2g4c) gene-deleted rats. However, since the function of Pla2g4c is unknown, the mechanism of regulation of breast cancer was analyzed using molecular biology techniques.
Lipocalin2 (Lcn2) expression was induced in Pla2g4c-knocked down rat mammary tumor cells, and Lcn2 was suggested to induce cell death. The results of various experiments showed that Pla2g4c suppressed Lcn2 via the NF-kappaB pathway.
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Report
(2 results)
Research Products
(17 results)
