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Development of novel molecular diagnosis methods of lung cancer by proteomic signature

Research Project

Project/Area Number 25640076
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Tumor diagnostics
Research InstitutionNagoya University

Principal Investigator

Yanagisawa Kiyoshi  名古屋大学, 医学系研究科, 講師 (20372112)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords肺癌 / プロテオミクス / 分子診断 / 非小細胞肺癌 / バイオマーカー / 悪性胸膜中皮腫 / バイオインフォマティクス / 翻訳語修飾
Outline of Final Research Achievements

We obtained protein expression profiles from both lung cancer and normal lung specimens. Based upon the information as well as clinical information, we conducted bioinformatic analyses. The resulting proteomic signature could accurately predict both disease-free and overall survival. Accordingly, we have discovered a proteomic signature that can distinguish NSCLC patients with a high risk from those with a favorable prognosis.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results)

  • [Journal Article] TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.2016

    • Author(s)
      Liu Z, Yanagisawa K, Griesing S, Iwai M, Kano K, Hotta N, Kajino T, Suzuki M, and Takahashi T.
    • Journal Title

      Oncogene

      Volume: 524 Issue: 26 Pages: 1-9

    • DOI

      10.1038/onc.2016.524

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blood-borne miRNA profile-based diagnostic classifier for lung adenocarcinoma.2016

    • Author(s)
      Tai MC, Yanagisawa K, Nakatochi M, Hotta N, Hosono Y, Kawaguchi K, Naito M, Taniguchi H, Wakai K, Yokoi K, Takahashi T.
    • Journal Title

      Scientific Report

      Volume: 6 Issue: 1 Pages: 1-9

    • DOI

      10.1038/srep31389

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] miR-342-3p regulates MYC transcriptional activity via direct repression of E2F1 in human lung cancer.2015

    • Author(s)
      Tai MC, Kajino T, Nakatochi M, Arima C, Shimada Y, Suzuki M, Miyoshi H, Yatabe Y, Yanagisawa K, Takahashi T.
    • Journal Title

      Carcinogenesis

      Volume: 36 Pages: 1464-1473

    • DOI

      10.1093/carcin/bgv152

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lung adenocarcinoma subtypes definable by lung development-related miRNA expression profiles in association with clinicopathologic features2014

    • Author(s)
      Arima C, Kajino T, Tamada Y, Imoto S, ShimadaY, Nakatochi, M, Suzuki M, Isomura H, Yatabe Y, Yamaguchi T, Yanagisawa K, Miyano S, Takahashi T
    • Journal Title

      Carcinogenesis

      Volume: 35 Issue: 10 Pages: 2224-2231

    • DOI

      10.1093/carcin/bgu127

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Quantitative proteomic profiling identifies DPYSL3 as pancreatic ductal adenocarcinoma-associated molecule that regulates cell adhesion and migration by stabilization of focal adhesion complex2013

    • Author(s)
      Kawahara T, Hotta N, Ozawa Y, Kato S, Kano K, Yokoyama Y, Nagino M, Takahashi T, Yanagisawa K
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 12 Pages: e79654-e79654

    • DOI

      10.1371/journal.pone.0079654

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] NKX2-1/TTF-1: an enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression2013

    • Author(s)
      Yamaguchi T, Hosono Y, Yanagisawa K, Takahashi T
    • Journal Title

      Cancer Cell

      Volume: 23 Issue: 6 Pages: 718-723

    • DOI

      10.1016/j.ccr.2013.04.002

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Proteomic identification of potential biomarkers of thoracic tumors2017

    • Author(s)
      Kiyoshi Yanagisawa
    • Organizer
      Fourth Annual US Japan Workshop on Cancer Biomarkers in Collaboration with NCI Early Detection Research Network
    • Place of Presentation
      Tempe Mission Palms Hotel and Conference Center Tempe, Arizona, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] プロテオミクス解析のがん研究への応用2016

    • Author(s)
      柳澤 聖
    • Organizer
      第7回Japan Mesothelioma Interest Group研究会
    • Place of Presentation
      KITTE名古屋、愛知県、名古屋市
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Proteomic identification of potential biomarkers of human lung malignancies2013

    • Author(s)
      Kiyoshi Yanagisawa and Takashi Takahashi
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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