Search for the cause of proteomic disorder without genomic mutations in the global mis-regulation of splicing
| Project/Area Number |
25640081
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnostics
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| Research Institution | Fujita Health University |
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Principal Investigator |
MAYEDA Akila 藤田保健衛生大学, 総合医科学研究所, 教授 (50212204)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMEYAMA Toshiki 藤田保健衛生大学, 総合医科学研究所, 助教 (60298544)
SHIROKI Ryoichi 藤田保健衛生大学医学部, 腎泌尿器外科学, 教授 (70226330)
SUGIOKA Atsushi 藤田保健衛生大学医学部, 肝脾外科学, 教授 (20171150)
UTSUMI Toshiaki 藤田保健衛生大学医学部, 乳腺外科学, 教授 (10176711)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 遺伝子発現調節 / スプライシング / mRNA / 品質管理機構 / 癌 |
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| Outline of Final Research Achievements |
We discovered re-splicing event in cancer cells that occurs on mature spliced mRNA and generates aberrant mRNAs. This ‘mRNA re-splicing’ event not only explains a global splicing mis-regulation in cancer, but also implies an mRNA-quality control mechanism that prevents deleterious extra re-splicing in normal cells. Therefore, we tried to search for the regulation factors of the mRNA re-splicing. Intriguingly, tumor suppressor p53 factor prevented mRNA re-splicing, while it was promoted by the epithelial-mesenchymal transition factor TGF-β. Our results suggest considerable implication of the mRNA re-splicing event in the progression and suppression of cancer.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] ETV6-LPXN fusion transcript generated by t(11;12)(q12.1;p13) in a patient with relapsing acute myeloid leukemia with NUP98-HOXA9.2016
Author(s)
Abe A, Yamamoto Y, Iba S, Kanie T, Okamoto A, Tokuda M, Inaguma Y, Yanada M, Morishima S, Mizuta S, Akatsuka Y, Okamoto M, Kameyama T, Mayeda A, Emi N.
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Journal Title
Genes, chromosomes & cancer
Volume: 55(3)
Issue: 3
Pages: 242-250
DOI
Related Report
Peer Reviewed
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[Journal Article] NUP214-RAC1 and RAC1-COL12A1 Fusion in Complex Variant Translocations Involving Chromosomes 6, 7 and 9 in an Acute Myeloid Leukemia Case with DEK-NUP214.2015
Author(s)
Abe A, Yamamoto Y, Iba S, Okamoto A, Tokuda M, Inaguma Y, Yanada M, Morishima S, Kanie T, Tsuzuki M, Akatsuka Y, Mizuta S, Okamoto M, Kameyama T, Mayeda A, Emi N.
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Journal Title
Cytogenetic and genome research
Volume: 146(4)
Issue: 4
Pages: 279-284
DOI
Related Report
Peer Reviewed
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