| Project/Area Number |
25640081
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Tumor diagnostics
|
|---|
| Research Institution | Fujita Health University |
|---|
Principal Investigator |
MAYEDA Akila 藤田保健衛生大学, 総合医科学研究所, 教授 (50212204)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KAMEYAMA Toshiki 藤田保健衛生大学, 総合医科学研究所, 助教 (60298544)
SHIROKI Ryoichi 藤田保健衛生大学医学部, 腎泌尿器外科学, 教授 (70226330)
SUGIOKA Atsushi 藤田保健衛生大学医学部, 肝脾外科学, 教授 (20171150)
UTSUMI Toshiaki 藤田保健衛生大学医学部, 乳腺外科学, 教授 (10176711)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 遺伝子発現調節 / スプライシング / mRNA / 品質管理機構 / 癌 |
|---|
| Outline of Final Research Achievements |
We discovered re-splicing event in cancer cells that occurs on mature spliced mRNA and generates aberrant mRNAs. This ‘mRNA re-splicing’ event not only explains a global splicing mis-regulation in cancer, but also implies an mRNA-quality control mechanism that prevents deleterious extra re-splicing in normal cells. Therefore, we tried to search for the regulation factors of the mRNA re-splicing. Intriguingly, tumor suppressor p53 factor prevented mRNA re-splicing, while it was promoted by the epithelial-mesenchymal transition factor TGF-β. Our results suggest considerable implication of the mRNA re-splicing event in the progression and suppression of cancer.
|
