Elucidation of regulatory mechanism of DNA repair factor to overcome intractable breast cancer
| Project/Area Number |
25640086
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Tumor therapeutics
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
Chiba Natsuko 東北大学, 加齢医学研究所, 教授 (50361192)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | BRCA1 / 抗がん剤感受性 / 乳がん / DNA損傷 / ユビキチン化 |
|---|
| Outline of Final Research Achievements |
BRCA1 is an important breast and ovarian cancer susceptibility gene. Hereditary cancers with BRCA1 mutations and sporadic c ancers with lower BRCA1 expression are sensitive to platinating agent and PARP inhibitor. We identified a novel BRCA1-interacting protein (BIP) and found that overexpression of BIP causes reduction of BRCA1 and BARD1, which is also BRCA1-interacting protein. Interestingly, the expression level of BRCA1 and BIP show a negative correlation in several cancer cell lines. These suggest that the expression level of BIP is a candidate of biomarkers or molecular targets of cancer chemotherapy.
|
Report
(4 results)
Research Products
(12 results)
-
[Journal Article] Regulation of centrosome cycle2016
Author(s)
Hiroki Fujita, Yuki Yoshino , and Natsuko Chiba
-
Journal Title
Molecular & Cellular Oncology
Volume: 3
Issue: 2
Pages: e1075643-e1075643
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
