Development of Therapeutic Bacteria Machine Packaging with the Production System of Anti-Cancer Protein
| Project/Area Number |
25640095
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Hidefumi Mukai 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー (60570885)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | がん治療 / 遺伝子改変細菌 / 抗がんタンパク / 癌治療 / 抗癌タンパク / 腫瘍環境応答 |
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| Outline of Final Research Achievements |
We successfully developed the B. choshinensis highly efficiently secreting murine tumor necrosis factor-alpha (TNF-alpha) and demonstrated its significant antitumor effects against the cultured TNF-sensitive L929 cells and a tendency to inhibit tumor growth in L929 bearing mice by intra-tumor injection. This is the original report showing the antitumor effects by engineered B. choshinensis, indicating that it is one of the potential bio-machines for synthetic biology and applied microbiology focusing on cancer therapy.
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Report
(4 results)
Research Products
(3 results)
