Genomic constrain and plasticity of vocal phenotypes by regulation of allelic imbalance
Project/Area Number |
25640097
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Genome biology
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Research Institution | Hokkaido University |
Principal Investigator |
Wada Kazuhiro 北海道大学, 理学(系)研究科(研究院), 准教授 (70451408)
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Co-Investigator(Renkei-kenkyūsha) |
MINETA Katsuhiko 北海道大学, 大学院情報科学研究科, 准教授 (40374615)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | 発声学習 / 対立遺伝子不均衡 / ソングバード / ハイブリッド / 種特異的遺伝子発現 / 個体差 / 環境要因 / 遺伝要因 / 遺伝子発現 / 種特異的 / 学習臨界期 |
Outline of Final Research Achievements |
Both nature and nurture influence the learning process. Birdsong is a learned vocal behavior that is regulated by species-specific genetic constraints and individual hearing experience. However, how and when genetic and environmental instructions contribute to modulate vocal learning is not well known. In this study, we developed hybrid songbirds, whose parental species sing different species-specific songs. The hybrid songbirds showed the full-spectrum of variability of song features of parental species. Based on this behavioral data, we further performed next-generation sequence (RNA-seq) from two brain areas related to regulation of song patterns. Then, we found species-specific SNPS and genes which were differently regulated in the brain areas between two parental species and hybrids. We are further working on the studying the allelic imbalance of the species-specifically regulated genes.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] A global view of the functional molecular organization of the avian cerebrum: Mirror images and functional columns.2013
Author(s)
Jarvis ED*, Yu J, Rivas MV, Horita H, Feenders G, Whitney O, Jarvis S, Jarvis ER, Kubikova L, Puck AE, Siang-Bakshi C, Martin S, McElroy M, Hara E, Howard J, Mouritsen H, Chen CC*, Wada K*.
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Journal Title
J Comp Neurol.
Volume: 521
Issue: 16
Pages: 3614-3665
DOI
Related Report
Peer Reviewed
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