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Transomic analysis of adaptation induced by a synthetic gene circuit

Research Project

Project/Area Number 25640110
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field System genome science
Research InstitutionKyushu University

Principal Investigator

ITO Takashi  九州大学, 医学(系)研究科(研究院), 教授 (90201326)

Co-Investigator(Kenkyū-buntansha) 太田 一寿  東京大学, 理学(系)研究科(研究院), 助教 (00322727)
Project Period (FY) 2013-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords人工遺伝子回路 / トランスオミクス / 適応 / ヒストンメチル化 / ミトコンドリア / レトロトランスポゾン / SAM
Research Abstract

The cell can adapt to various environmental changes and stably inherit the adapted states to the daughter cells. It has been long argued that such adaptation stems from the plasticity of gene circuits and that mutations play a role in fixation of the state in the population. We used a synthetic gene circuit to expose yeast cells to a selection pressure and found that they can stably maintain an adapted state even after its withdrawal. To address the mechanism underlying this phenomenon, we took a transomic analysis that integratively examines the layers of the genome DNA, chromatin, and RNAs, and revealed evidence for potential involvement of movable genetic elements, histone modifications and mitochondria.

Report

(2 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (2 results)

All 2013

All Presentation (2 results)

  • [Presentation] 人工遺伝子回路によって誘導される適応現象のトランスオミクス解析2013

    • Author(s)
      梅山大地、伊藤隆司
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2013-12-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 人工遺伝子回路によって誘導される適応現象のトランスオミクス解析2013

    • Author(s)
      梅山大地、伊藤隆司
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Annual Research Report

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Published: 2014-07-25   Modified: 2016-11-25  

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