High-throughput screening for protein complexes recognizing codes of epigenetic modifications
| Project/Area Number |
25640111
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
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| Research Institution | University of Fukui |
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Principal Investigator |
HONDA Shinji 福井大学, テニュアトラック推進本部, 助教 (90632167)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | DNAメチル化 / アカパンカビ / ヒストン修飾 / エピジェネティクス / エピジェネティク |
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| Outline of Final Research Achievements |
It has been proposing that multiple combinations of modifications of DNA and/or histones work as codes to direct various biological phenomena. Although the modifications has been known to be recognized by specific protein(s), the multiple code recognition system remains unclear. In this study, we developed a system to identify proteins associated with specific genomic domains such as centromeres which are modified using mutants lacking DNA and/or histone modifications in Neurospora. Furthermore, we found novel recognition machineries using the system, verifying the utility.
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Report
(3 results)
Research Products
(6 results)
