| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
Recent advances in genome research clearly show that many genes originate de novo from non-genic DNA sequences. However, little is known about scenarios of the origination. We have sketched here a putative scenario of how genes arose from non-genic sequences by applying bioinformatics analysis to Saccharomyces cerevisiae genome. That is, we have reconstructed the homologous ancestral DNA sequences before and after de novo gene origination and have observed changes between the two sequences. A putative scenario which we have successfully sketched is as follows. (1)In the beginning was GC-rich genome region. (2)Neutral mutations were accumulated in the region. (3)ORFs were extended/combined, and then (4)translation signature (Kozak sequence) was recruited.
|
