| Project/Area Number |
25640115
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
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| Research Institution | Okayama University |
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Principal Investigator |
HISAO Moriya 岡山大学, 異分野融合先端研究コア, 准教授 (60500808)
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| Co-Investigator(Kenkyū-buntansha) |
KITO Keiji 明治大学, 農学部, 講師 (40345632)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 酵母 / タンパク質過剰 / プロセス負荷 / 局在化 / 細胞内局在 / 過剰発現 |
|---|
| Outline of Final Research Achievements |
Strong expression of a protein in a cell sometimes causes cellular defects. However, it is not systematically understood the mechanisms causing the defects. In this study, we discovered that the strong expression of proteins localized to intracellular compartments caused cellular defects due to the burdens for protein localization processes themselves.
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