Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Outline of Final Research Achievements |
We studied the molecular mechanism how mammalian cells sense and transduce osmotic stress information, using ASK3 as an original probe. According to the results obtained from genome-wide siRNA screenings for ASK3 regulators, it is suggested that hypo- and hyper-tonic stress are received by different system. Moreover, we found that an unexpected molecule is involved in the signal transduction of hypertonic stress. Our results contribute to the comprehensive understanding of osmotic stress response in the mammalian cells and blood pressure regulation, which is closely related to the osmotic stress-responsive molecules such as ASK3.
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