| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
This study aimed to elucidate the growth-promoting mechanism of action mechanism of neural stem cells with tissue kallikrein. In this study, We found that kallikrein inhibited NF-kappa B pathway of neural stem cells. As a result of examining the pathways that activate NF-kappa B pathway, we found that kallikrein cleaved the IL-1 type I receptor. Activation of the NF-κB pathway has been reported to promote the differentiation of neural stem cells. These results suggests that suppressing the differentiation of neural stem cells by kallikrein increases the apparent cell growth rate in neural stem cells.
|
